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Table 4 Cox proportional model for survival until death from breast cancer at 10 years time.

From: Use of immunohistochemical markers can refine prognosis in triple negative breast cancer

   

Univariate

Full Multivariate

Parsimonious

Model

Variable

RR (95% CI)

P

RR (95% CI)

P

RR (95% CI)

P

Model 1

CK5/6+ and/or EGFR+

No

1.

 

1.

 

1.

 
  

Yes

2.00 [1.33; 3.02]

0.0009

1.95 [1.18; 3.21]

0.009

1.92 [1.27; 2.89]

0.002

 

TNP

No

1.

 

1.

   
  

Yes

1.71 [1.05; 2.78]

0.03

0.96 [0.51; 1.79]

0.89

not present

 

Model 2

PR

No

1.

 

1.

 

1.

 
  

Yes

0.59 [0.40; 0.85]

0.005

0.64 [0.42; 0.98]

0.04

0.62 [0.42; 0.92]

0.02

 

CBP

No

1.

 

1.

   
  

Yes

1.72 [1.06; 2.80]

0.03

1.18 [0.64; 2.17]

0.60

not present

 

Model 3

ER- HER2-

No

1.

 

1.

 

1.

 
  

Yes

1.96 [1.30; 2.97]

0.002

1.41 [0.80; 2.49]

0.24

1.64 [0.99; 2.70]

0.05

 

PR

No

1.

 

1.

   
  

Yes

0.59 [0.40; 0.85]

0.005

0.77 [0.49; 1.20]

0.24

not present

 
 

CK5/6+ and/or EGFR+

No

1.

 

1.

 

1.

 
  

Yes

2.00 [1.33; 3.02]

0.0009

1.54 [0.92; 2.58]

0.10

1.69 [1.04; 2.74]

0.03

  1. All statistical modeling adjust for variables with missing values (see methods). The full multivariate model also includes terms for centre, age of diagnosis, histological grade, tumor size and lymph node. Parsimonious model was assumed when all P-values were below 10%. All three parsimonious models also included terms for tumor size and lymph node status. Parsimonious model-2 also included a term for Histological grade while parsimonious model-3 also included a term for the centre. The total number of subjects is 456. The total number of events is 111 at 10 years.
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BMC Cancer

ISSN: 1471-2407

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