Table 3 The most significantly altered pathways in melanoma cells.

up-regulated

230

Purine metabolism

Nucleotide Metabolism

119

11

23

4.37E-05

440

Aminophosphonate metabolism

Metabolism of Other Amino Acids

12

0

6

0.000153

626

Nitrobenzene degradation

Biodegradation of Xenobiotics

11

0

5

0.00098

363

Bisphenol A degradation

Biodegradation of Xenobiotics

16

0

6

0.00101

350

Tyrosine metabolism

Amino Acid Metabolism

44

6

10

0.00196

450

Selenoamino acid metabolism

Metabolism of Other Amino Acids

20

0

6

0.00370

52

Galactose metabolism

Carbohydrate Metabolism

27

2

7

0.00429

4540

Gap junction

Cell Communication

85

4

14

0.00670

340

Histidine metabolism

Amino Acid Metabolism

31

1

7

0.00964

4110

Cell cycle

Growth and Death

98

2

15

0.01009

Down-regulated

190

Oxidative phosphorylation

Energy Metabolism

128

46

8

2.95E-27

193

ATP synthesis

Energy Metabolism

42

14

4

2.68E-08

720

Reductive carboxylate cycle

Energy Metabolism

10

6

0

5.25E-06

20

Citrate cycle (TCA cycle)

Carbohydrate Metabolism

26

9

2

6.56E-06

620

Pyruvate metabolism

Carbohydrate Metabolism

35

8

5

0.00057

240

Pyrimidine metabolism

Nucleotide Metabolism

72

12

12

0.00057

660

C5-branched dibasic acid metabolism

Carbohydrate Metabolism

2

2

0

0.00319

480

Glutathione metabolism

Metabolism of Other Amino Acids/Neutralization of ROS*

37

7

1

0.00400

280

Valine, leucine and isoleucine degradation

Amino Acid Metabolism

39

7

6

0.00543