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Table 2 Expression profile of lymphangioma LECs compared to HUVECs using Agilent gene micro-arrays

From: Elevated expression of VEGFR-3 in lymphatic endothelial cells from lymphangiomas

Molecule

Patient A

P-Value

Patient B

P-Value

LEC markers

    

Prox1

5.21

3.2779e-05

5.34

3.0458e-05

 

5.00

0.000114

5.47

8.7549e-05

Podoplanin

7.26

0.000538

6.23

0.000847

Reelin

5.64

0.000634

5.12

0.000844

c-Maf

4.45

0.000177

5.17

0.000113

Macrophage mannose receptor

3.96

0.000157

4.48

0.000109

TIMP 3

5.60

2.3392e-05

5.80

2.1012e-05

Lyve-1

2.75

0.001547

1.89

0.004617

VEGFR-3

1.73

0.009537

2.38

0.003869

 

2.54

0.000704

3.30

0.000323

Growth factors and receptors

    

VEGFR-2

1.91

0.005006

4.18

0.000506

 

1.33

0.085223

4.08

0.004490

Neuropilin-2

1.59

0.000646

2.89

0.000107

 

1.47

0.001513

3.34

0.000133

 

1.19

0.009847

3.09

0.000614

FGF-12

1.56

0.001699

2.67

0,000344

 

0.98

0.005359

2.59

0,000304

TGF-α

5.03

0.000273

5.32

0.000230

Integrin-α9

2.46

0.000592

2.35

0.000677

 

1.15

0.002815

1.70

0.000912

Integrin-α1

4.22

0.003322

2.69

0.011953

VEGFR-2 and -3 signalling

    

SHC

2.34

0.000219

3.20

8.6303e-05

 

1.73

0.000303

2.50

0.000100

PLCγ-1

1.80

0.000291

0.69

0.004961

PLCγ-2

n.r.

-

1.27

0.005680

MAPK3/ERK1

0.40

0.029350

1.63

0.000559

MAPK1/ERK2

-0.84

0.005289

-0.62

0.012707

 

-0.45

7.9235e-06

-0.21

8.2757e-05

NF-kappaB1

0.27

0.026460

0.85

0.000982

 

0.29

0.047104

1.16

0.001010

  1. The up-regulation is expressed as the log2 ratio as compared to HUVECs. For MAPK1 we observed down-regulation. All values (except one written in italic) are statistically significant. Double values refer to transcription variants of the gene. n.r. = not regulated.