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Table 2 Optimised radiotherapy (hyperfractionation or acceleration) with or without simultaneous chemotherapy using cisplatin, carboplatin, mitomycin C, and 5-FU as single drug or combinations of 5-FU with one of the other drugs (Group 1b, no significant difference in overall treatment time between treatment arms)

From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck

  

control arm

experimental arm

  

publication

trial #

dose [Gy]

RT time [days]

dose [Gy]

RT time [days]

DDP

Carbo

5-FU

FA

MMC

Stage 4 [%]

neck N3 [%]

Jeremic [33]

11

77

49

77

49

210

    

82

18

Brizel [34]

12

75

42

70

40

120

 

6000

   

13

Wendt [35]

13

70.2

56

70.2

56

180

 

4200

1350

  

14

Staar [36]

14

69.4

38

69.4

38

 

700

6000

  

96

10

Dobrowsky [37]

15

55.3

17

55.3

17

    

20

82

13

Budach [12]

16

77.6

42

70.4

42

  

3000

 

20

94.5

14

  1. DDP = cisplatin cumulative dose [mg/m2]; Carbo = carboplatin cumulative dose [mg/m2]; 5-FU = 5-fluorouracil cumulative dose [mg/m2]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m2]