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Table 1 Conventionally fractionated radiotherapy with or without simultaneous chemotherapy using cisplatin, carboplatin, mitomycin C, and 5-FU as single drug or combinations of 5-FU with platinum-derivate (group 1a)

From: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck

  

control arm

experimental arm

  

publication

trial #

dose [Gy]

RT time [days]

dose [Gy]

RT time [days]

DDP

Carbo

5-FU

FA

MMC

stage 4 [%]

neck N3 [%]

Sanchiz [18]

1

60

42.0

60

42.0

  

3750

   

30

Lo [24]

2

66

56.0

66

56.0

  

5500

  

41

38

Browman [25]

3

66

45.5

66

45.5

  

7200

  

55

14

Jerimic [26]

4

70

50.8

70

50.8

222

    

86

16

Adelstein [27]

5

70

49.0

70

49.0

300

    

94

28

Jeremic [26]

6

70

50.8

70

50.8

 

925

   

86

19

Grau [28]

7

66

47.0

66

47.0

    

30

53

4

Adelstein [29]

8

70

49.0

70

49.0

160

 

8000

  

72

31

Olmi [30]

9

68

47.3

68

47.25

 

900

12000

  

75

7

Denis, Calais [31,32]

10

70

49.0

70

49.0

 

840

7200

  

68

13

  1. DDP = cisplatin cumulative dose [mg/m2]; Carbo = carboplatin cumulative dose [mg/m2]; 5-FU = 5-fluorouracil cumulative dose [mg/m2]; FA = folinic acid; MMC = mitomycin C cumulative dose [mg/m2]