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Table 1 Sensitivity of MCA (*≥11 or **≥15 U/mL cut-off values), CEA, TPA, CA15.3 in the early detection of 19 relapses during an intensive post-operative follow-up with tumour markers.

From: Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases

 

CE or PI of tumour markers as the initial pathological finding of relapse

Tumour marker type

aRelapses (total, n)

Sensitivity (%)

Tumour marker increase

Lead time (months) m + sd (range)

   

type

n

 

*MCA

13

68

CE

PI

8

5

7.1 ± 6.8

(0–22)

CEA

2

10

CE

PI

0

2

2.0 ± 2.8

(0–4)

TPA

5

26

CE

PI

3

2

3.2 ± 4.4

(0–9)

CA15.3

6

32

CE

PI

5

1

4.7 ± 5.8

(0–14)

**MCA

10

53

CE

PI

7

3

6.5 ± 6.8

(0–18)

CEA

3

16

PI

3

7.3 ± 9.4

(0–18)

TPA

8

42

CE

PI

6

2

2.9 ± 4.0

(0–9)

CA15.3

6

32

CE

PI

5

1

4.7 ± 5.8

(0–14)

  1. aTotal number of patients = 18; one patient after radical removal by surgery of a single metastatic lesion relapsed (also see Result section). Therefore, percentages are calculated on 19 relapses; CE = constant elevation; PI = progressive increase.