Figure 1

Association between MTHFR genotypes and breast cancer survival after stratification by ER-status. Shown are the Kaplan-Meier survival curves. (a) Cumulative survival of ER-negative patients by C677T status (n = 101). The survival of patients who carry the variant C677T genotype (n = 30; C/T or T/T) is significantly better than the survival of patients with the common genotype (n = 71; C/C). Log-rank test: p = 0.04. (b) Cumulative survival of ER-positive patients by C677T status (n = 144). The survival of patients who carry the variant C677T genotype (n = 50) is not significantly different from the survival of patients with the common genotype (n = 94). Log-rank test: p = 0.95. (c) Cumulative survival of ER-negative patients by A1298C status (n = 101). The survival of patients who carry the variant A1298C genotype (n = 38; A/C or C/C) is significantly worse than the survival of patients with the variant genotype (n = 63; A/A). Log-rank test: p = 0.02. (d) Cumulative survival of ER-positive patients by A1298C status (n = 143). The survival of patients who carry the variant A1298C genotype (n = 70) is not significantly different from the survival of patients with the common genotype (n = 73). Log-rank test: p = 0.68.