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Table 2 Mean normalized ERCC1, OGG1 and RAI mRNA levels in normal colonic mucosa and lesions.

From: Increased mRNA expression levels of ERCC1, OGG1 and RAIin colorectal adenomas and carcinomas

 

ERCC1

  

OGG1

  

RAI

  
 

Mean level × 1000a

  

Mean level × 1000a

  

Mean level × 1000a

  

Type of tissue

Normal

Lesions

Pb

95% CI

Normal

Lesions

Pb

95% CI

Normal

Lesions

Pb

95% CI

All cases combined

0.55

1.8

0.005

(0.4 ;2.2)

0.33

1.83

3*10 -5

(0.9 ; 2.1)

0.26

2.0

0.0005

(0.8 ; 2.7)

Adenomasc

            

   Mild/moderate

0.76

2.2

0.151

(-0.9 ; 3.5)

0.44

2.13

0.069

(-0.2 ; 3.6)

0.31

3.1

0.135

(-1.6 ; 6.6)

   Severe

0.39

1.5

0.027

(0.15 ; 2.1)

0.35

1.68

0.004

(0.5 ; 2.2)

0.28

1.85

0.0014

(0.4 ; 1.5)

CRC

0.16

1.5

0.109

(-0.4 ; 3.1)

0.24

1.83

0.034

(0.2 ; 3.0)

0.18

1.46

0.09

(-0.3 ; 2.8)

  1. a) Since ERCC1, OGG1 and RAI expression is expressed as a ratio, normalized, to 18S rRNA expression, it is unit-less.
  2. b) Comparison of the expression levels in lesions and normal colonic mucosa from the same persons.
  3. c) The adenomas are divided in groups according to mild/moderate dysplasia or severe dysplasia.
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BMC Cancer

ISSN: 1471-2407

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