Polymorphisms of XRCC1 genes and risk of nasopharyngeal carcinoma in the Cantonese population

BMC Cancer

Table 2 Association between risk of NPC and XRCC1 genotypes among cases and controls

Genotype	Cases No. (%)^a	Controls No. (%)^b	Unadjusted OR	Adjusted OR^c (95%CI)	P value
*XRCC1*Arg194Trp
Arg/Arg	232(55.7)	235 (47.5)	1.00	1.00
Arg/Trp	166(39.8)	217(43.8)	0.80	0.79(0.60–1.05)	0.10
Trp/Trp	19(4.5)	43(8.7)	0.48	0.48(0.27–0.86)	0.01*
Allele of Trp	0.24	0.31
*XRCC1* Arg399Gln
Arg/Arg	241(56.7)	270(53.9)	1.00	1.00
Arg/Gln	152(35.8)	201(40.1)	0.81	0.82(0.62–1.08)	0.16
Gln/Gln	32(7.5)	30(6.0)	1.20	1.20(0.69–2.06)	0.53
Allele of Gln	0.25	0.26

^a 417 cases and 495 controls were eligible tested in condon 194 genotype variant.
^b 425 cases and 501 controls were eligible tested in condon 399 genotype variant.
^c Adjusted OR were calculated with the XRCC1 194Arg/Arg or 399Arg/Arg genotype as the reference group and adjusted for age, sex, smoking status.
*P-value remained significant after Bonferroni's correction.

ISSN: 1471-2407