Table 2 Dose-limiting toxicities (DLTs) according to dose level.
Dose level (5-FU/day) | Pts/cycles | After first cycle | After all courses (pts/cycles) | ||||
|---|---|---|---|---|---|---|---|
| Â | Â | Â | Neutropenia | FN1 | stomatitis | diarrhea | asthenia |
Level 1 (250 mg) | 3/4 | None | Â | Â | 1/1 | Â | 1/1 |
Level 2 (500 mg) | 10/35 | Stomatitis (1) | 4/5 | Â | 6/11 | 1/1 | 4/7 |
Level 3 (750 mg) | 3/4 | Stomatitis (1) FN (1) | 2/2 | 1/1 | 2/2 | 1/1 | 1/1 |