Differential gene expression profile reveals deregulation of pregnancy specific β1 glycoprotein 9 early during colorectal carcinogenesis

Table 3 Genes differentially expressed within different adenomas compared to corresponding normal mucosa.

Gene's name	Description	A1	A2	A3
GAS1	growth arrest-specific 1	↓	↑	↓
IGFBP2	insulin-like growth factor binding protein 2	↓	↑	↓
MAPRE3	microtubule-associated protein, RP/EB family, member 3	↑	↓	↓
ZFYVE20	zinc finger, FYVE domain containing 20	↑	↑	↓
FLJ11848	hypothetical protein FLJ11848	↓	↓	↑
KIAA1750	KIAA1750 protein	↓	↓	↑
KIAA1941	KIAA1941 protein	↓	↑	↓

Differentially expressed genes identified in adenomas compared to corresponding normal tissue. In total, 84 genes showed significant differential expression in all three adenomas compared to normal-appearing epithelial cells (p < 0.05). Thirty-seven genes were up-regulated (Table 1), and 47 down-regulated (Table 2). PSG9 showed a consistent 2-fold over-expression in all adenomas compared to normal mucosa (p < 0.006).

ISSN: 1471-2407