Table 5 Pattern of compliance to chemotherapy by age and radiotherapy
Variable | Age | Radiotherapy | ||||
|---|---|---|---|---|---|---|
>60 and < 65 (n = 100) | ≥ 65 (n = 80) | P§ | No* (n = 114) | Yes (n = 66) | P§ | |
N. of cycles administered, no. (%) | 0.42 | 0.01 | ||||
6 cycles | 81 (81) | 61 (76) | 84 (74) | 58 (88) | ||
5 cycles | 5 (5) | 4 (5) | 4 (3) | 5 (8) | ||
4 cycles | 4 (4) | 4 (5) | 6 (5) | 2 (3) | ||
3 cycles | 5 (5) | 6 (8) | 10 (9) | 1 (1) | ||
2 cycles | 4 (4) | 4 (5) | 8 (7) | 0 | ||
1 cycle | 1 (1) | 1 (1) | 2 (2) | 0 | ||
N. of day 8 omitted, no. (%) | 0.37 | 0.86 | ||||
0 | 69 (69) | 51 (64) | 77 (68) | 43 (65) | ||
1 | 23 (23) | 18 (22) | 24 (21) | 17 (26) | ||
2 | 5 (5) | 8 (10) | 9 (8) | 4 (6) | ||
3 | 3 (3) | 3 (4) | 4 (3) | 2 (3) | ||
Rate of cycles at reduced dose, no. (%) | 0.54 | 0.83 | ||||
≤ 25% | 86 (86) | 66 (82) | 97 (85) | 55 (83) | ||
>25% | 14 (14) | 14 (18) | 17 (15) | 11 (17) | ||
Actual/planned duration, no. (%) | 0.59 | 0.05 | ||||
≤ 1.25 | 99 (99) | 78 (98) | 114 (100) | 63 (95) | ||
>1.25 | 1 (1) | 2 (2) | 0 | 3 (5) | ||
G-CSF utilization, no. (%) | 0.12 | <.0001 | ||||
No | 91 (91) | 66 (82) | 109 (96) | 48 (73) | ||
Yes | 9 (9) | 14 (18) | 5 (4) | 18 (27) | ||
Treatment discontinuation, no. (%) | 0.52 | 0.10 | ||||
protocol completion | 81 (81) | 61 (76) | 84 (74) | 58 (88) | ||
patient's refusal | 6 (6) | 9 (11) | 12 (11) | 3 (4) | ||
treatment toxicity | 11 (11) | 7 (9) | 13 (11) | 5 (8) | ||
other | 2 (2) | 3 (4) | 5 (4) | 0 | ||
Low compliance†, no. (%) | 0.02 | 0.88 | ||||
No | 61 (61) | 34 (42) | 61 (54) | 34 (52) | ||
yes | 39 (39) | 46 (58) | 53 (46) | 32 (48) | ||