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Table 4 Multivariate model of factors associated with undergoing aggressivea treatment for clinically localized cancer (n = 2796).

From: Differences between men with screening-detected versus clinically diagnosed prostate cancers in the USA

Variable

Received aggressive treatment

Wald F P-value

 

Adjusted percentages (95% CI)

Odds ratio (95% CI)

 

Screening history

  

0.05

   Not-screened

76 (74, 78)

1.0

 

   Screened

70 (64, 76)

1.5 (1.1 – 2.3)

 

SEER registry

  

< 0.01

   Los Angeles

71 (67, 75)

1.0

 

   Atlanta

89 (85, 93)

4.8 (2.7 – 8.5)

 

   Connecticut

77 (73, 81)

1.5 (1.1 – 2.2)

 

   New Mexico

72 (66, 78)

1.1 (0.7 – 1.7)

 

   Seattle

73 (67, 79)

1.2 (0.8 – 1.8)

 

   Utah

77 (73, 81)

1.5 (1.0 – 2.3)

 

Ethnicity

  

< 0.01

   Non-Hispanic white

76 (74, 78)

1.0

 

   Non-Hispanic black

69 (63, 75)

0.6 (0.4 – 0.9)

 

   Hispanic

79 (75, 83)

1.2 (0.8 – 1.9)

 

Age

  

< 0.01

   < 49

95 (92, 100)

1.0

 

   50–64

89 (87, 91)

0.4 (0.2 – 1.2)

 

   65–74

79 (77, 81)

0.2 (0.1 – 0.5)

 

   75+

41 (35, 47)

0.03 (0.01 – 0.08)

 

Current marital status

  

< 0.01

   Married

77 (75, 79)

1.0

 

   Unmarried

71 (67, 75)

0.6 (0.5 – 0.8)

 

Education

  

0.95

   < High school degree

76 (72, 80)

1.0

 

   High school/college

76 (74, 78)

1.0 (0.7 – 1.3)

 

   College degree

76 (72, 80)

0.9 (0.7 – 1.4)

 

Insurance

  

0.25

   Private

76 (74, 78)

1.0

 

   Medicare/Public

74 (68, 80)

0.9 (0.6 – 1.4)

 

   Unknown

81 (75, 87)

1.6 (0.9 – 2.8)

 

Income (annual)

  

0.98

   < $20,000

76 (72, 80)

1.0

 

   $20 – 40,000

76 (72, 80)

1.0 (0.7 – 1.4)

 

   $40,000 +

76 (72, 80)

1.0 (0.7 – 1.5)

 

Comorbid conditions

  

0.01

   None

78 (74, 82)

1.0

 

   1

77 (73, 81)

0.9 (0.7 – 1.2)

 

   2

77 (73, 81)

0.9 (0.6 – 1.3)

 

   3+

68 (62, 74)

0.5 (0.3 – 0.7)

 

Health status

  

< 0.01

   Excellent

80 (76, 84)

1.0

 

   Good

77 (75, 79)

0.8 (0.5 – 1.2)

 

   Fair or poor

67 (61, 73)

0.4 (0.3 – 0.7)

 

PSA (ng/ml)

  

< 0.01

   <4

69 (63, 75)

1.0

 

   ≥ 4

77 (75, 79)

1.7 (1.1 – 2.6)

 

   Unknown

68 (60, 76)

0.9 (0.5 – 1.9)

 

Gleason score

  

< 0.01

   2 – 4

68 (62, 74)

1.0

 

   5 – 7

78 (76, 80)

2.0 (1.4 – 2.8)

 

   8 – 10

71 (65, 77)

1.2 (0.7 – 2.0)

 

   Unknown

80 (74, 86)

2.3 (1.3 – 4.2)

 
  1. aAggressive treatment was defined as radical prostatectomy or radiation therapy.
  2. Legend: SEER = Surveillance, Epidemiology, and End Results; PSA = prostate-specific antigen