Figure 7From: Transformation of human bronchial epithelial cells alters responsiveness to inflammatory cytokines Effect of OSM and macrophage factors on DNA synthesis of normal and abnormal epithelial cells. A, Normal epithelial cells (25 cultures) and B abnormal epithelial cells (8 metaplasia and 2 dysplasia) were treated with serially diluted OSM or conditioned macrophage medium and the incorporation of [3H]thymidine determined. All values expressed relative to the untreated cultures in each series. C, Paired cultures of normal and dysplastic epithelial cells (EC-65) were analyzed by immunoblotting for OSM-stimulated ERK phosphorylation and the same cells for inhibition of [3H]thymidine incorporation by OSM and macrophage-factors (mean and range of duplicate values)Back to article page