TP53 mutations in ovarian carcinomas from sporadic cases and carriers of two distinct BRCA1 founder mutations; relation to age at diagnosis and survival

Table 2 TP53 mutations, survival and histopathological features for each case.

Case	^a BRCA1 carrier type	Stage	^bGrade	Type	TTGE	Exon	Codon	Mutation	aa change	Age of diagnosis	^cSurvival months	^dVital status
3453	1	3	2	ser	pos	5		559+1G>A	splice	53	83	1
10	1	3	3	ser	pos	6	213	CGA>TGA	arg>stop	65	22	3
2857	1	3	3	ser	pos	6	213	CGA>TGA	arg>stop	53	83	3
4	1	4	3	ser	pos	6	216	GTG>ATG	val>met	59	11	3
27	1	2	3	endo	pos	7	237	ATG>ATA	met>ile	39	61	3
8 ^e	1	3	3	ser	pos	7	260	TCC>TCT	ser>ser	49	84	3
						8	306	CGA>TGA	arg>stop
14	1	1	3	ser	pos	8	267	CGG>CAG	arg>gln	51	25	3
13	1	4	3	ser	pos	8	273	CGT>AGT	arg>ser	39	15	3
29	1	3	3	mix	pos	8	273	CGT>TGT	arg>cys	50	36	3
2842	1 1	4	3	ser	pos	8	273	CGT>TGT	arg>cys	39	35	3
21	1	3	3	ser	pos	8	293	GGG>AGG	gly>arg	39	21	3
26	1	3	2	ser	pos		intron	G>A	ivs5	53	93	1
9	1	4	2	ser	neg					50	39	3
11	1	3	3	ser	neg					44	8	3
17	1	3	3	ser	neg					47	30	3
24	1	2	4	ser	neg					59	20	3
34	1	1	3	ser	neg					46	120	1
30	1	1	2	ser	neg					43	199	2
32	1	2	3	ser	neg					48	108	1
3351	1	4	3	endo	neg					44	9	3
1	2	4	3	ser	pos	5	144	CAG>TAG	gln>stop	41	1	3
3	2	3	3	uncl	pos	6	196	CGA>TGA	arg>stop	48	46	3
20	2	3	3	ser	pos	6	205	TAT>TCT	tyr>ser	52	36	3
28	2	4	3	ser	pos	7	261	AGG>AGA	arg>arg	80	12	3
7 ^e	2	3	3	ser	pos	7	255	ATC>GTC	ile>val	58	30	3
						5	141	TGC>TGT	cys>cys
12	2	1	3	ser	pos	8	280	AGA>GGA	arg>gly	49	134	1
15	2	3	3	ser	pos		intron	C>T	ivs7	50	19	3
5	2	4	3	ser	neg					60	45	3
18	2	2	3	endo	neg					44	117	3
22	2	3	2	mix	neg					47	96	3

a: 1 = 1675delA and 2 = 1135insA. b: undifferentiated (4). c: all patients were followed until diseased or to 15^th April, 2004. d: alive without cancer (1), alive with cancer (2), and dead by cancer (3). e: two different mutations detected in sample.

ISSN: 1471-2407