Modeling the effect of age in T1-2 breast cancer using the SEER database

BMC Cancer

Table 4 Results of GAM and proportional hazards tests for GBSG-2 data

GBSG-2 data set	no transform	transform age+\|age-50\|^1.5	transform age+\|age-50\|^1.8
Hazard ratio for Age	1.001	1.004	1.002
p-value of Hazard ratio for Age	0.92	0.019	0.010
GAM Chisq for Age	31.74	9.29	8.70
GAM p-value for Age	0.0000006	0.0256	0.0336
Test PH for Age: rho	0.131	0.0459	0.0240
Test PH for Age: chisq	6.118	0.581	0.169
Full PH model Rsquare	0.135	0.142	0.143
Full PH model Likelihood ratio test	99.7	105	106

Chisq = chi-square value, GAM = generalized additive model, GBSG-2 = German Breast Cancer Study Group, PH = proportional hazards. The Additional file 2 "outputgbsg2.doc" lists the other covariates included in the PH models.

ISSN: 1471-2407