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Table 1 Chymotryptic 26S Proteasome Activity in Lysates from ECV 304 Cells

From: Anthracyclines, proteasome activity and multi-drug-resistance

μM

Doxorubincin

Daunorubicin

Epirubicin

Idarubicin

0

1

1

1

1

6.25

0.92 ± 0.03*

0.85 ± 0.05*

0.79 ± 0.1 n.s.

0.97 ± 0.03 n.s.

12.5

0.84 ± 0.05*

0.53 ± 0.11*

0.57 ± 0.31 n.s.

0.96 ± 0.02 n.s.

25

0.72 ± 0.04**

0.22 ± 0.09**

0.59 ± 0.14*

0.79 ± 0.12 n.s.

50

0.59 ± 0.1*

0.12 ± 0.06**

0.36 ± 0.2*

0.28 ± 0.09 **

100

0.36 ± 0.03***

0.11 ± 0.06**

0.27 ± 0.17*

0.1 ± 0.06 **

  1. n.s. not significant, *p < 0.05, **p < 0.01, ***p < 0.001 (two-sided student's t-test)