Figure 4

Hierarchical clustering of relative expression ratios for four biomarker transcripts. This mosaic depicts association between patient samples and relative expression of the 4 potential biomarker transcripts. Natural log-transformed SYBR Green RT-PCR ratio data (relative expression of day 56: day 1) were used in analysis. In the color scheme, higher ratios are indicated in red, lower ones in green (scale ranges from -4 to +4). Results from individual patients are oriented as rows and transcripts are oriented as columns. Red bars on the right side of the map indicate cases from the SU5416 arm. The hierarchical clustering method is average linkage and the distance metric is Euclidean. A table containing the relative expression values that were used in the clustering analysis can be viewed (see Additional File 1).