Figure 4

PKC inhibitors augment the accumulation of [ ³ H]vincristine in SK-N-BE(2) cells. Different concentrations of LY379196, GF109203X and Gö6976 were added to SK-N-BE(2) cells 15 min prior to a 2 h incubation with [³H]vincristine. The amount of the radioactivity that had accumulated in the cells was thereafter measured. Data are expressed as percent of [³H]vincristine that had accumulated in cells that had not been exposed to inhibitor and are mean ± SEM of 8 determinations.