Figure 2

The effect of the combination of LY379196 and anticancer drugs on neuroblastoma cell growth. IMR-32, SH-SY5Y, and SK-N-BE(2) cells were grown in medium supplemented with increasing concentrations of doxorubicin, etoposide, paclitaxel, vincristine, and carboplatin. Different amounts of LY379196 were also included in the medium yielding final concentrations of 0 (■, black), 20 (●, red), 100 (▲, green) or 500 (▼, blue) nM. After three (SK-N-BE(2)) or four (IMR-32 and SH-SY5Y) days in culture the amount of viable cells was analyzed with an MTT assay. The concentrations of the anticancer drugs are indicated on the x-axes as lg([drug]/1M). Data are expressed as percent of values obtained in the absence of drugs and are mean ± SEM (n = 8–9).