Figure 4

Combinatorial therapy prolongs survival in RIP1-Tag2 mice. Effect of treatment on survival in (A) 10 week old (intervention) and (B) 13 week old (regression) RIP1-Tag2 mice. Between 10–12 mice were tested in each cohort. In the intervention trial (A), cohorts were treated with: untreated (closed circles, n = 12), 600R (open triangles, n = 10), TCR splenocytes + 600R (closed squares, n = 10) and TCR splenocytes + 600R (x2) (x, n = 10) and allowed to age until they became moribund. Statistical analysis was done using a log-rank test. P values comparing experimental groups to untreated control mice are TCR+600R (<0.0001) and TCR+600R(x2) (0.0003). In the regression trial (B), cohorts were treated as above with an additional control group C3H splenocytes + 600R (closed diamonds, n = 10) and allowed to age until they became moribund. The sample sizes are: untreated control, n = 12; 600R alone, n = 11; TCR splenocytes + 600R, n= 16; TCR splenocytes + 600R (x2), n = 9. P values comparing experimental groups to untreated control mice are TCR+600R (0.001) and TCR+600R(x2) (0.0715).