BMC Cancer

Table 4 Univariate, backwards elimination and multiple cox PH model of proteins assessed by IHC

From: Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer

PFS
Variable	Univariable			Backwards elimination			Multiple Cox PH model
	HR^a	95% CI	p-value	HR^a	95% CI	p-value	HR^a	95% CI	p-value
APOE epithelium	0.90	0.82-1.0	0.011	0.82	0.74-0.90	0.0007	0.82	0.74-0.90	0.0007
APOE stroma	1.34	1.10-1.63	0.002	1.48	1.22-1.79	0.0001	1.48	1.22-1.79	0.0001
AGT epithelium	0.90	0.82-1.0	0.006	0.90	0.82-1.0	0.006
AGT stroma	0.90	0.82-1.10	0.579
DBP epithelium	1.00	0.90-1.10	0.753
DBP stroma	1.10	0.90-1.34	0.201
OS
APOE epithelium	0.90	0.82-1.0	0.179	0.90	0.82-1.0	0.043	0.90	0.82-1.0	0.04
APOE stroma	1.22	1.0-1.48	0.036	1.22	1.10-1.48	0.012	1.22	1.10-1.48	0.01
AGT epithelium	0.90	0.82-1.0	0.90
AGT stroma	1	0.90-1.22	0.67
DBP epithelium	1.0	0.90-1.10	0.58
DBP stroma	1.22	1.0-1.34	0.037	1.22	1.0-1.34	0.037

^aHazard ratio were calculated based on a ten percent change in protein expression.
Abbreviations: AGT angiotensinogen, APOE apolipoprotein E, DBP vitamin D binding protein.

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