Skip to main content

Table 1 Number of AR CAG repeats and ESR2 CA repeats and associated colorectal cancer risk in the female and male study population

From: Repeat polymorphisms in ESR2 and ARand colorectal cancer risk and prognosis: results from a German population-based case-control study

 

Overall

Women

Men

 

Genotype

Cases N

Controls N

OR (95% CI)b

Cases N

Controls N

OR (95% CI)c

Cases N

Controls N

OR (95%CI)c

pheterogeneity

AR CAG( n)

    

<20 average repeats

263

254

1.00 (Ref.)

88

94

1.00 (Ref.)

175

160

1.00 (Ref.)

 

≥20 to <22 average repeats

531

506

1.01 (0.82 - 1.25)

229

228

1.06 (0.75 - 1.51)

302

278

1.00 (0.76 - 1.31)

 

≥22 to <23.5 average repeats

370

400

0.89 (0.71 - 1.11)

182

189

1.03 (0.72 - 1.48)

188

211

0.82 (0.61 - 1.10)

 

≥23.5 average repeats

424

412

0.99 (0.79 - 1.23)

169

140

1.24 (0.85 - 1.80)

255

272

0.86 (0.65 - 1.13)

0.19d

average repeatsa

1588

1572

0.99 (0.96 - 1.01)

668

651

1.01 (0.96 - 1.06)

920

921

0.98 (0.95 - 1.01)

0.23e

   

p trend =0.34

  

p trend =0.68

  

p trend =0.15

 

<22/<22 repeats

645

610

1.00 (Ref.)

168

172

1.00 (Ref.)

477

438

1.00 (Ref.)

 

<22/≥22 repeats

324

324

0.91 (0.72 - 1.15)

324

324

1.03 (0.79 - 1.35)

n/a

n/a

(no heterozygous)

 

≥22/≥22 repeats

619

638

0.91 (0.78 - 1.07)

176

155

1.14 (0.84 - 1.55)

443

483

0.84 (0.70 - 1.01)

0.09e

   

p trend =0.24

  

p trend =0.40

  

p trend =0.07

 

ESR2 CA( n)

          

<22 average repeats

348

409

1.00 (Ref.)

149

153

1.00 (Ref.)

199

256

1.00 (Ref.)

 

≥22 to <23.5average repeats

389

381

1.20 (0.98 - 1.47)

154

154

1.07 (0.77 - 1.49)

235

227

1.25 (0.96 - 1.64)

 

≥23.5 to <24 average repeats

226

227

1.17 (0.93 - 1.48)

98

90

1.14 (0.77 - 1.68)

128

137

1.20 (0.87 - 1.65)

 

≥24 average repeats

618

602

1.20 (1.00 - 1.45)

261

255

1.06 (0.78 - 1.46)

357

347

1.31 (1.02 - 1.70)

0.51d

average repeatsa

1581

1619

1.05 (1.01 - 1.10)

662

652

1.01 (0.95 - 1.08)

919

967

1.07 (1.02 - 1.13)

0.24e

   

p trend =0.02

  

p trend =0.69

  

p trend =0.01

 

<24/<24 repeats

323

347

1.00 (Ref.)

119

125

1.00 (Ref.)

204

222

1.00 (Ref.)

 

<24/≥24 repeats

755

814

0.99 (0.83 - 1.19)

335

334

1.03 (0.77 - 1.39)

420

480

0.95 (0.75 - 1.20)

 

≥24/≥24 repeats

503

458

1.17 (0.96 - 1.43)

208

193

1.10 (0.80 - 1.52)

295

265

1.21 (0.94 - 1.55)

0.71e

   

p trend =0.08

  

p trend =0.54

  

p trend =0.11

 
  1. aAs continuous variable, bModels adjusted for sex, county of residence and age, cModels adjusted for county of residence and age, d P value for heterogeneity by gender with genotype in categories (3 df), e P value for heterogeneity by gender with genotype as continuous variable (1 df), OR: odds ratio, CI: confidence interval.
Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us