Figure 1

Fever range hyperthermic shock induces large-scale changes in gene expression in breast cancer and mammary epithelial cells. (A) Heatmap depicting the 7252 two-fold or greater changes in gene expression (p < 0.05) occurring in the C vs H and C’ vs H’ comparisons. Hierarchical clustering based on cell lines shows the degree of similarity with respect to gene expression clustering for each indicated cell line (red?=?overexpressed, green?=?underexpressed). (B) Venn diagram illustrating common and unique 2-fold or greater gene expression changes (p < 0.05) between each of the cell lines in the C vs H and C’ vs H’ comparison. (C) Profile plot of the normalized intensity values for each two-fold or greater gene expression change (p < 0.05) showing relative expression for each cell line in the in the C vs H and C’ vs H’ comparison.