Global miRNA expression analysis of serous and clear cell ovarian carcinomas identifies differentially expressed miRNAs including miR-200c-3p as a prognostic marker

Table 5 **Interacting miRNAs and mRNAs in HGSC - differentially* and inversely expressed**

miRNAs and mRNA targets	FC values
miR-134^1,5	-16.7
KLHL14¹, PAX8 ^1,3,5	9.6 – 29.3
miR-141-3p ^1,2,6/ miR-200a-3p ^1,2,6	46.1
FOXP2 ^1,2,5, HLF¹, PCDH9⁵, PEG3 ^1,6, SCN7A¹, SDC2^1,2,3,4,5,6	-9.6 – -24.7
miR-182-5p ^1,2	30.2
ANGPTL1^1,2,5, CACNB2^1,5, FOXP2 ^1,2,5, KCNMB2^1,5, PID1¹, SDC2^1,2,3,4,5,6, TMEM150C	-9.6 – -14.6
miR-183-5p ^1,2,6	11.7
ABCA8 ¹, HLF¹	-11.6 – -17.8
miR-187-3p¹	12.8
TSPAN5^1,2	-11.3
miR-200b-3p ^1,2,6/ miR-200c-3p ^1,2,6	29.1
CACNB2^1,5,CDH11^1,2,5,6, COL4A3^1,2,5,6, GPM6A¹, HLF¹, HS3ST3A1¹, LEPR^1,2,4,5,6, MCC^1,2, NEGR1^1,2,6, SDC2^1,2,3,4,5,6	-9.6 – -21.6
miR-202-3p	-36.9
RRM2 ^1,2,4,6	16.9
miR-203-3p ^1,2,6	13.6
ANGPTL1^1,2,5, EDNRA^1,2,6, FOXP2 ^1,2,5,GNG4^2,6, IGFBP5^1,2,3,4,5,6, NEGR1^1,2,6, SMAD9¹	-9.7 – -15.0
miR-205-5p ^1,6	105.1
BAMBI^1,2,5,6, NR3C2^1,2,5,6, PEG3 ^1,6	-10.1 – -24.7
miR-376c-3p¹	-11.7
EHF^1,2,3,6, LRP8 ^1,5,6	11.9 – 12.6
miR-379-5p	-10.3
KLHL14¹	29.3
miR-381-3p¹	-12.6
EGFL6¹, NOTCH3 ^1,2,3,5,6, RRM2 ^1,2,4,6	9.7 – 16.9
miR-383	-33.7
MAL2	32.8
miR-424-5p ^1,2,3,4,5,6	-26.0
AHNAK2¹, CCNE1 ^1,2,3,4,6, ESRP1 ^1,6, HMGA1 ^1,2,3,4,6, LAMP3^1,2, PSAT1 ¹, UCP2 ^2,5, VAMP8^1,2	9.9 – 24.0
miR-485-5p¹	-13.6
KRT7^1,3,4, LRP8 ^1,5,6, ST14¹	10.5 – 16.2
miR-887	-9.6
TMEM139	11.7
miR-4324	-12.5
ERBB3 ^1,2,3,5,6, GALNT6	17.9 – 23.7

HGSC: High-grade serous ovarian carcinoma. *ANOVA, FDR < 5%, FC ≥ ±10 in HGSC vs. ovarian surface epithelium. All interactions are of high predicted confidence, whereas the interactions between miR-424-5p and CCNE1, HMGA1, PSAT1 and UCP2 are experimentally observed. ^{1, 2, 3, 4, 5, 6}Related to cancer (italicized for ovarian cancer), cellular growth and proliferation, cell cycle, DNA replication, recombination and repair, cell-to-cell signaling and interaction, cellular development, respectively. Results were generated through the use of Ingenuity Pathway Analysis.

ISSN: 1471-2407