Table 1 Summary of the different case–control association studies targeting the mtDNA polymorphism m.10398A > G. statistical power was computed using mitPower
From: The saga of the many studies wrongly associating mitochondrial DNA with breast cancer
Reference | Population/Ethnicity | No. of cases | No. of controls | Power (%) | ‘Risky’ allele |
|---|---|---|---|---|---|
(frequency of A10398) | (frequency of A10398) | ||||
[12] | ‘African-Americans’ | 48 (15%) | 54 (6%) | 15.1 | None |
‘African-Americans’ | 654 (13%) | 605 (9%) | 98.4 | A | |
‘Whites’ | 879 (80%) | 760 (79%) | 100 | None | |
Non-Jewish European American | 156 (68%) | 260 (79%) | 66.1 | G | |
[14] | Tamil Nadu; South India | 279 (38%) | 280 (45%) | 97.8 | None |
Andhra Pradesh, South India | 348 (46%) | 352 (45%) | 99.2 | None | |
Karnataka, South India | 89 (38%) | 92 (42%) | 59.1 | None | |
[5] | Spanish mainland | 464 (84%) | 453 (82%) | 94.9 | None |
Canary Island (Spain) | 302 (76%) | 295 (78%) | 88.5 | None | |
[20] | North India | 124 (57%) | 273 (44%) | 85.6 | A |
[18] | ‘African-American’ | 542 (7%) | 282 (4%) | 49.4 | None |
Multi-ethnic cohort | 391 (7%) | 460 (6%) | 78.2 | None | |
CARE and LIFE cohort | 524 (6%) | 236 (7%) | 72.1 | None | |
[21] | Polish | 44 (77%) | 100 (97%) | 0.1 | G |
[22] | Southern Chinese | 28 (26.9%) | 45 (39.5%) | 25.3 | None |
[23] | Bangladesh; India | 24 (75%) | 20 (35%) | 16.7 | A |
[24] | Iraq | 21 (100%) | 16 (100%) | 11.2 | None |
Iraq | 21 (100%) | 22 (91%) | 0 | None | |
[25] | Malay | 101 (27%) | 90 (46%) | 61.4 | G |