Author | Year | Type | n | f/u | Pre RT | GTR | Boost | 5-year-LC | 5-year-OS |
---|
Pawlik1
| 2006 | Pro.,comb. | 72 | 40 | 89% | 79% | 44% | 60%* | 61%* |
Gronchi24
| 2014 | Pro. | 83 | 58 | 88% | 95% | 17% | 63% | 59% |
Smith25
| 2014 | Pro.,subgr. | 40 | 106 | 100% | 100% | 48% | 63% (cr) | 70% |
Tzeng26
| 2006 | Pro. | 16 | 28 | 100% | 88% | 0% (d) | 80% (2Â yr) | n.s. |
McBride27
| 2013 | Retro. | 33 | 33 | 100% | 100% | 30% | 63% (3Â yr) | 64% (3Â yr) |
Sweeting28
| 2013 | Retro. | 18 | 43 | 94% | 100% | 100% | 64% | 72% |
Alford29
| 2012 | Retro. | 24 | 28 | 100% | 75% | 0% | 68% | 54% |
Present data | 2014 | Pro.,interim | 27 | 33 | 93% | 96% | 85% | 72% | 74% |
- pro.: prospective trial, comb., combined analysis, subgr.: subgroup analysis, interim: interims analysis, n: number of patients, f/u: median follow-up in months, pre RT: percentage of patients with completion of preoperative radiation therapy as planned, GTR: percentage of patients in whom gross total resection was achieved, boost: percentage of patients who received an additional boost via IORT or Brachytherapy, d: preoperative radiation therapy was dose escalated, LC: local control, OS: Overall survival, *: in grossly resected patients, cr: crude rate, 2Â yr: 2-year rate, 3Â yr: 3-year rate.