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Table 2 Family history of cancer and risk of esophageal and gastric adenocarcinoma

From: Family history of cancer and gastroesophageal disorders and risk of esophageal and gastric adenocarcinomas: a case–control study

History of cancer among first degree relatives

 

EA

GCA

DGA

Controls

Cases

OR (95% CI)a

P a

Cases

OR (95% CI)a

P a

Cases

OR (95% CI)a

P a

Any cancer

          

 No

668

68

1.00 (ref)

 

90

1.00 (ref)

 

160

1.00 (ref)

 

 Yes

629

78

1.02 (0.68-1.54)

0.92

91

1.04 (0.71-1.53)

0.83

122

0.83 (0.60-1.15)

0.27

 Late-onset

481

58

0.96 (0.62-1.49)

0.85

63

0.96 (0.63-1.46)

0.84

89

0.81 (0.56-1.16)

0.25

 Early-onset

148

20

1.24 (0.66-2.35)

0.50

28

1.33 (0.74-2.38)

0.34

33

0.90 (0.54-1.48)

0.67

Gastrointestinal cancer

          

Any gastrointestinal cancerb

          

 No

1101

125

1.00 (ref)

 

148

1.00 (ref)

 

226

1.00 (ref)

 

 Yes

196

21

0.87 (0.48-1.59)

0.66

33

1.19 (0.71-1.97)

0.51

56

1.45 (0.95-2.23)

0.087

 Late-onset

153

16

0.85 (0.44-1.65)

0.63

26

1.23 (0.70-2.14)

0.47

40

1.31 (0.80-2.16)

0.28

 Early-onset

43

5

0.98 (0.29-3.33)

0.97

7

1.04 (0.36-3.02)

0.95

16

1.84 (0.90-3.78)

0.095

Esophageal cancer

          

 No

1290

145

1.00 (ref)

 

176

1.00 (ref)

 

280

1.00 (ref)

 

 Yes

7

1

-

-

5

5.18 (1.23-21.79)

0.025

2

-

-

Gastric cancer

          

 No

1241

141

1.00 (ref)

 

171

1.00 (ref)

 

260

1.00 (ref)

 

 Yes

56

5

0.92 (0.32-2.65)

0.87

10

1.57 (0.72-3.45)

0.26

22

2.15 (1.18-3.91)

0.012

Colorectal cancer

          

 No

1222

138

1.00 (ref)

 

171

1.00 (ref)

 

260

1.00 (ref)

 

 Yes

75

8

0.94 (0.39-2.27)

0.89

10

0.70 (0.27-1.79)

0.46

22

1.21 (0.61-2.39)

0.59

Liver cancer

          

 No

1267

139

1.00 (ref)

 

179

1.00 (ref)

 

276

1.00 (ref)

 

 Yes

30

7

1.94 (0.64-5.83)

0.24

2

-

-

6

0.51 (0.13-2.01)

0.34

Pancreatic cancer

          

 No

1275

145

1.00 (ref)

 

176

1.00 (ref)

 

276

1.00 (ref)

 

 Yes

22

1

-

-

5

1.55 (0.44-5.43)

0.49

6

2.17 (0.72-6.51)

0.17

Non-gastrointestinal cancer

          

Lung cancer

          

 No

1202

132

1.00 (ref)

 

164

1.00 (ref)

 

267

1.00 (ref)

 

 Yes

95

14

1.03 (0.48-2.24)

0.93

17

0.92 (0.43-1.98)

0.84

15

1.05 (0.52-2.11)

0.90

Upper respiratory organ cancer

          

 No

1172

128

1.00 (ref)

 

157

1.00 (ref)

 

260

1.00 (ref)

 

 Yes

125

18

0.98 (0.50-1.93)

0.96

24

1.22 (0.67-2.20)

0.51

22

1.02 (0.57-1.85)

0.94

Skin/bone/connective tissue cancer

          

 No

1225

141

1.00 (ref)

 

174

1.00 (ref)

 

272

1.00 (ref)

 

 Yes

72

5

0.61 (0.21-1.74)

0.35

7

0.44 (0.14-1.46)

0.18

10

1.06 (0.40-2.79)

0.90

Lymphatic/hematopoietic cancer

          

 No

1256

141

1.00 (ref)

 

179

1.00 (ref)

 

272

1.00 (ref)

 

 Yes

41

5

1.49 (0.56-3.96)

0.43

2

-

-

10

0.90 (0.32-2.55)

0.84

Prostate cancer

          

 No

1224

130

1.00 (ref)

 

170

1.00 (ref)

 

272

1.00 (ref)

 

 Yes

73

16

2.84 (1.50-5.36)

0.001

11

1.45 (0.70-3.01)

0.32

10

0.44 (0.17-1.16)

0.10

Breast cancer

          

 No

1168

137

1.00 (ref)

 

167

1.00 (ref)

 

258

1.00 (ref)

 

 Yes

129

9

0.60 (0.28-1.28)

0.19

14

0.68 (0.33-1.40)

0.30

24

0.78 (0.42-1.45)

0.44

Female reproductive organ cancer

          

 No

1228

132

1.00 (ref)

 

167

1.00 (ref)

 

263

1.00 (ref)

 

 Yes

67

14

1.59 (0.72-3.51)

0.25

13

1.56 (0.74-3.27)

0.24

17

1.02 (0.52-2.02)

0.94

Unknown primary site

          

 No

1234

139

1.00 (ref)

 

176

1.00 (ref)

 

270

1.00 (ref)

 

 Yes

63

7

0.76 (0.29-1.99)

0.58

5

0.54 (0.19-1.54)

0.25

12

0.80 (0.38-1.66)

0.55

  1. Abbreviations: EA, esophageal adenocarcinoma; GCA, gastric cardiac adenocarcinoma; DGA, distal gastric adenocarcinoma; OR, odds ratio; CI, confidence interval.
  2. aResults were estimated from multivariate polytomous logistic regression, with adjustment for age, sex, race, education, birth place, cigarette smoking status, body mass index, history of diabetes, and history of other malignancies. History of cancer among first degree relatives was unknown for 17 participants.
  3. bGastrointestinal cancer includes malignant neoplasm of the gastrointestinal tract, including esophagus, stomach, small intestine, colon, rectum, rectosigmoid junction, anus, liver, gallbladder, intrahepatic and extrahepatic bile ducts, pancreas, and other and ill-defined sites within the digestive organs and peritoneum.
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BMC Cancer

ISSN: 1471-2407

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