Table 2 Univariate Cox proportional hazards regression analysis

Age, (≥47 vs. < 47 years)

0.73

0.51 to 1.06

0.100

0.87

0.56 to 1.33

0.517

0.85

0.56 to 1.29

0.444

Male vs. Female

1.08

0.71 to 1.65

0.726

1.48

0.86 to 2.54

0.162

0.92

0.64 to 1.65

0.922

Histology, WHO type (III vs. II)

0.95

0.42 to 2.53

0.949

0.69

0.28 to 1.70

0.689

1.78

0.56 to 5.62

0.328

ECOG (2 vs. 0–1)

1.10

0.15 to 7.85

0.927

1.05

0.36 to 6.53

0.596

1.25

0.14 to 8.99

0.824

Clinical stage (III-IV) vs. (I-II)

3.05

1.34 to 6.94

0.008

4.43

1.40 to 14.01

0.011

2.56

1.04 to 6.31

0.041

Tumour stage (T3-4 vs. T1-2)

1.47

0.93 to 2.31

0.100

1.65

0.94 to 2.88

0.08

1.32

0.80 to 2.18

0.286

Node stage (N2-3 vs. N0-1)

1.72

1.19 to 2.48

0.004

2.19

1.40 to 3.42

0.001

1.75

1.16 to 2.66

0.008

Chemoradiotherapy (yes v no)

1.94

0.90 to 4.17

0.089

1.58

0.69 to 3.63

0.279

1.59

0.70 to 3.64

0.27

IMRT vs. 2DRT/3DCRT

0.55

0.38 to 0.80

0.002

0.66

0.42 to 1.04

0.071

0.88

0.57 to 1.34

0.537

High DNA Vs. Low DNA

2.97

2.02 to 4.36

< 0.001

3.69

2.30 to 5.91

< 0.001

3.50

2.23 to 5.50

< 0.001

CRP, mg/L (≥1.61vs. < 1.61)

1.43

0.99 to 2.06

0.055

1.83

1.18 to 2.84

0.007

1.87

1.23 to 2.85

0.003

VCA-IgA (≥1:80 vs. < 1:80)

1.39

0.91 to 2.13

0.127

1.32

0.81 to 2.16

0.267

0.95

0.64 to 1.61

0.952

EA-IgA (≥1:10 vs. < 1:10)

1.23

0.85 to 1.77

0.282

1.17

0.76 to 1.81

0.477

0.99

0.66 to 1.50

0.977

LDH, U/L (≥167 vs. < 167)

1.41

0.98 to 2.04

0.064

1.67

1.07 to 2.59

0.002

1.38

0.92 to 2.08

0.125

D-dimer, ug/L (≥0.8 vs. < 0.8)

1.88

1.28 to 2.77

0.001

2.16

1.38 to 3.36

0.001

1.98

1.29 to 3.04

0.002

WBC, 109/L (≥6.7 vs. < 6.7)

1.06

0.90 to 1.25

0.753

1.17

0.76 to 1.9

0.481

1.08

0.72 to 1.62

0.709

Neutrophil, 109/L (≥4.1 vs. < 4.1)

1.09

0.76 to 1.56

0.658

1.03

0.67 to 1.57

0.9

1.24

0.82 to 1.87

0.308

HGB, g/l (≥143.8 vs. < 143.8)

0.87

0.61 to 1.25

0.463

0.82

0.53 to 1.25

0.35

0.77

0.51 to 1.16

0.207

PLT, 109/L (≥227 vs. < 227)

1.13

0.79 to 1.62

0.511

1.08

0.71 to 1.66

0.712

1.23

0.82 to 1.84

0.33

Smoking (yes vs. no)

1.27

0.88 to 1.84

0.196

1.59

1.04 to 2.44

0.033

1.22

0.81 to 1.84

0.346

Chronic HBV Infection (yes vs. no)

1.00

0.84 to 1.18

0.953

1.02

0.84 to 1.23

0.881

0.97

0.80 to 1.18

0.969

cardiovascular disease (yes v no)

1.16

0.61 to 2.22

0.653

1.28

0.62 to 2.67

0.5

1.64

0.79 to 3.41

0.184

Diabetes mellitus (yes v no)

0.94

0.85 to 1.05

0.286

0.97

0.87 to 1.08

0.592

0.94

0.84 to1.05

0.248

family history of NPC (yes v no)

1.14

0.61 to 2.11

0.686

1.13

0.55 to 2.35

0.735

1.14

0.92 to 1.41

0.241