Figure 1
The level of MIC-1 in PDAC tissue and serum samples. a. Upregulation of MIC-1 in tumor tissues and corresponding normal samples in PDAC (y-axis: the MIC-1 mRNA expression level, described as 2-△Ct with log10 scale axis). b. Scatter plots showing the correlation between relative expression of MIC-1 levels in serum (y-axis: log10 scale) and matched tumor tissues (x-axis: log 10 scale) obtained from 64 patients. A positive correlation was found by Spearman correlation (r = 0.569; P < 0.001). c. Relationship between serum MIC-1 and MIC-1 overexpression in 64 patients with PDAC. d. Comparison of serum MIC-1 levels between the patients with PDAC and different controls. Serum MIC-1 levels of patients with PDAC are significantly higher than that of different controls. e. Serum MIC-1 in other malignant neoplasms, including eight kinds of common tumors. In the box plots, the lines denote 10th, 25th, median, 75th and 90th percentiles for each, using the Mann–Whitney U test.