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Table 1 Diagnosis at follow-up among underscreened women by HPV status and concomitant cytology at baseline

From: Protecting the underscreened women in developed countries: the value of HPV test

NEGATIVE HPV TEST AT BASELINE

TOTAL SAMPLE N (%)

TOTAL FOLLOW UP SAMPLE N (%)

DIAGNOSIS AT LAST FOLLOW UP

NORMAL N (%)

ASC-US/ASC-H N (%)

CIN1aN (%)

CIN2a

CIN3aN (%)

CERVICAL CARCINOMAabN (%)

OTHERS RESULTScN (%)

CONCOMITANT CYTOLOGY RESULT AT BASELINE

Normal

1693 (99.1)d

654 (98.2)

641 (98.3)e

1 (100)

1 (100)

1 (100)f

  

10 (90.9)

 

ASC-US/ASC H/AGC/LSIL

15 (0.8)

11 (1.7)

10 (1.5)

     

1 (9.1)

 

Suspected adenocarcinomag

1 (0.1)

1 (0.2)

1 (0.2)

      
 

TOTAL

1709 (100)

666 (100)

652 (100)

1 (100)

1 (100)

1 (100)

  

11 (100)

POSITIVE HPV TEST AT BASELINE

TOTAL SAMPLE N (%)

TOTAL FOLLOW UP SAMPLE N (%)

       

CONCOMITANT CYTOLOGY RESULT AT BASELINE

Normal

99 (80.5)d

78 (77.2)

45 (83.3)

6 (100)

2 (25.0)

6 (75)

3(42.9)

 

16 (100)

 

ASC-US/AGC/LSIL

19 (15.4)

18 (17.8)

9 (16.7)

 

5 (62.5)

1 (12.5)

1 (14.3)

2 (100)

 
 

HSIL

5 (4.1)

5 (5.0)

  

1 (12.5)

1 (12.5)

3 (42.9)

  
 

TOTAL

123 (100)

101 (100)

54 (100)

6 (100)

8 (100)

8 (100)

7 (100)

2 (100)

16 (100)

  1. aAll the CIN1, CIN2, CIN3 and cervical cancer cases was histologically confirmed.
  2. bOne of the cases was an infiltrating squamous carcinoma (stage II) diagnosed at 23 months after cytology and HPV testing at baseline. The other case was an adenocarcinoma (stage I) diagnosed one month after study entry.
  3. cAmong negative HPV women, there were 3 cases of endometrial carcinoma who underwent a hysterectomy, 7 hysterectomies (5 for leiomyomatosis and 2 for prolapse) and one case with second positive HPV test. Among positive HPV women, there were a case with a hysterectomy for prolapse and 15 women with a persistent HPV infection.
  4. dThere were included in this group 23 women whose concomitant cytology at baseline had unsatisfactory results but during the follow up period, all subsequent tests were negative. There was one case in HPV positive arm.
  5. eTwo cases with normal concomitant and negative HPV test at baseline developed endometrial carcinoma during the follow-up period, but follow-up cytologies were normal. Another case with normal concomitant cytology and negative HPV test developed a VIN3 although Pap smears performed during the follow-up period were normal
  6. fCIN2 was developed after 54 months of cytology and HPV testing at baseline. Conisation was performed but no further data was available.
  7. gFinally the suspected of adenocarcinoma was a endometrial carcinoma, but follow-up cytologies were normal.
  8. ASC-US: Atypical squamous cell of undetermined significance, ASC-H: Atypical squamous cells cannot exclude a high grade squamous intraepithelial lesion, AGC: Atypical glandular cells of undetermined significance, HPV+: positive for Human Papillomavirus test, CIN-NOS: CIN not otherwise specified, CIN1: high grade cervical intraepithelial lesions grade 1, LSIL: low grade squamous intraepithelial lesion, CIN1: high grade cervical intraepithelial lesions grade 1, CIN2: high grade cervical intraepithelial lesions grade 2, CIN3: high grade cervical intraepithelial lesions grade 3, HSIL: High grade squamous intraepithelial lesion.
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BMC Cancer

ISSN: 1471-2407

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