Table 3 Association between ADAM8 expression in CRC and clinicopathologic characteristics (n = 342)
Indicator | ADAM8 expression | χ2 | pvalue | |
|---|---|---|---|---|
Negative (n = 81) | Positive (n = 261) | |||
Gender | Â | Â | 1.448 | 0.229 |
  Male | 49(60.5%) | 138(52.9%) |  |  |
  Female | 32(39.5%) | 123(47.1%) |  |  |
Age | Â | Â | 0.769 | 0.380 |
  ≤65 yrs | 51(63.0%) | 150(57.5%) |  |  |
  >65 yrs | 30(37.0%) | 111(42.5%) |  |  |
Location | Â | Â | 0.646 | 0.421 |
  Colon | 42(52.9%) | 122(46.7%) |  |  |
  Rectum | 39(48.1%) | 139(53.3%) |  |  |
T stage | Â | Â | 0.465 | 0.495 |
  T1-T2 | 16(19.8%) | 43(16.5%) |  |  |
  T3- T4 | 65(80.2%) | 218(83.5%) |  |  |
N stage | Â | Â | 1.675 | 0.196 |
  N0 | 54(66.7%) | 153(58.7%) |  |  |
  N1- N2 | 27(33.3%) | 108(41.3%) |  |  |
M stage | Â | Â | 0.256 | 0.613 |
  M0 | 68(84.0%) | 225(86.2%) |  |  |
  M1 | 13(16.0%) | 36(13.8%) |  |  |
TNM stage | Â | Â | 0.544 | 0.909 |
  I | 8(9.9%) | 33(12.6%) |  |  |
  II | 33(40.7%) | 107(41.0%) |  |  |
  III | 28(34.6%) | 83(31.8%) |  |  |
  IV | 12(14.8%) | 38(14.6%) |  |  |
Differentiation grade | Â | Â | 2.863 | 0.239 |
  Well | 5(12.3%) | 25(7.8%) |  |  |
  Moderately | 71(75.4%) | 207(83.0%) |  |  |
  Poorly | 5(12.3%) | 29(9.2%) |  |  |
Histological type | Â | Â | 1.209 | 0.272 |
  Adenocarcinoma | 72(88.9%) | 219(83.9%) |  |  |
  Mucinous/Signet-ring adenocarcinoma | 9(11.1%) | 42(16.1%) |  |  |
CA19-9 (ug/L) | Â | Â | 3.582 | 0.058 |
  ≤60 | 67(82.2%) | 236(90.4%) |  |  |
  >60 | 14(17.8%) | 25(9.6%) |  |  |
CEA (ug/L) | Â | Â | 0.225 | 0.635 |
  ≤5 | 52(64.2%) | 175(67.0%) |  |  |
  >5 | 29(35.8%) | 86(33.0%) |  |  |