|  | API5 |  |  | pERK1/2 |  | ||
---|---|---|---|---|---|---|---|---|
No. | % | Mean scores (95% CI) | P value | No. | % | Mean scores (95% CI) | P value | |
All study subjects | 850 | 100 | 3.53 (3.35-3.71) | Â | 793 | 100 | 2.45 (2.27-2.63) | Â |
Diagnostic category | Â | Â | Â | <0.001 | Â | Â | Â | <0.001 |
Normal | 411 | 48.3 | 2.44 (2.23-2.65) | Â | 382 | 48.1 | 1.69 (1.54-1.85) | Â |
Low grade CIN | 67 | 7.9 | 3.79 (3.23-4.36) | Â | 57 | 7.2 | 2.65 (2.17-3.13) | Â |
High grade CIN | 220 | 25.9 | 4.19 (3.88-4.50) | Â | 204 | 25.7 | 3.32 (2.95-3.69) | Â |
Cancer | 152 | 17.9 | 5.39 (4.92-5.87) | Â | 150 | 19.0 | 3.13 (2.53-3.73) | Â |
FIGO stage | Â | Â | Â | 0.004 | Â | Â | Â | 0.205 |
I | 102 | 67.1 | 4.88 (4.35-5.42) | Â | 99 | 66.0 | 2.89 (2.16-3.62) | Â |
II | 41 | 27.0 | 6.17 (5.14-7.20) | Â | 44 | 29.3 | 3.30 (2.19-4.40) | Â |
IV | 9 | 5.9 | 7.67 (5.39-9.94) | Â | 7 | 4.7 | 5.43 (1.06-9.79) | Â |
Cell type | Â | Â | Â | 0.533 | Â | Â | Â | 0.114 |
SCC | 122 | 80.3 | 5.32 (4.78-5.86) | Â | 124 | 82.7 | 3.35 (2.65-4.04) | Â |
Others | 30 | 19.7 | 5.70 (4.58-6.82) | Â | 26 | 17.3 | 2.08 (1.09-3.07) | Â |
Tumor grade | Â | Â | Â | <0.001 | Â | Â | Â | 0.237 |
Well + Moderate | 94 | 64.4 | 4.69 (4.12-5.26) |  | 96 | 65.3 | 2.78 (2.07-3.49) |  |
Poor | 52 | 35.6 | 6.62 (5.80-7.44) | Â | 51 | 34.7 | 3.53 (2.44-4.62) | Â |
Tumor size | Â | Â | Â | 0.932 | Â | Â | Â | 0.776 |
≤ 4 cm | 105 | 69.1 | 5.38 (4.82-5.94) |  | 103 | 68.7 | 3.07 (2.37-3.77) |  |
> 4Â cm | 47 | 30.9 | 5.43 (4.47-6.38) | Â | 47 | 31.3 | 3.26 (2.07-4.44) | Â |
LN metastasis | Â | Â | Â | 0.385 | Â | Â | Â | 0.637 |
No | 104 | 76.5 | 5.00 (4.45-5.55) | Â | 102 | 75.0 | 2.71 (2.02-3.40) | Â |
Yes | 32 | 23.5 | 5.53 (4.24-6.82) | Â | 34 | 25.0 | 2.38 (1.25-3.52) | Â |
Chemoradiation | Â | Â | Â | 0.004 | Â | Â | Â | 0.216 |
Good response | 29 | 80.6 | 3.41 (2.27-4.56) | Â | 31 | 81.6 | 1.39 (0.66-2.11) | Â |
Bad response | 7 | 19.4 | 7.00 (5.81-8.19) | Â | 7 | 18.4 | 0.43 (-0.07-0.92) | Â |
HPV test in CIN | Â | Â | Â | 0.951 | Â | Â | Â | 0.940 |
Negative | 28 | 12.4 | 4.14 (3.19-5.10) | Â | 28 | 13.7 | 3.07 (2.12-4.02) | Â |
Positive | 198 | 87.6 | 4.17 (3.85-4.49) | Â | 177 | 86.3 | 3.11 (2.76-3.45) | Â |