Figure 10
From: Hypoxia represses microRNA biogenesis proteins in breast cancer cells
Mature and precursor expression in hypoxia vs. normoxia. A, Pre-let-7a and mature let-7a expression, precursor/mature ratio in MCF7 cells exposed to hypoxia (0.1% O2 for 48 h) vs. normoxia. B, Pre-miR-21 and miR-21 expression, precursor/mature ratio in MCF7 cells exposed to hypoxia (0.1% O2 for 48 h) vs. normoxia. C, Pre-miR-185 and miR-185 expression, precursor/mature ratio in MCF7 cells exposed to hypoxia (0.1% O2 for 48 h) vs. normoxia. Data represent normalized mean ± S.E (error bars) (n = 3). miRNA levels were analysed by RT-PCR and normalised to RNU6B levels.