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Table 1 Correlation between lenvatinib treatment-dependent changes in plasma biomarkers and AUC

From: Pharmacodynamic change in plasma angiogenic proteins: a dose-escalation phase 1 study of the multi-kinase inhibitor lenvatinib

Plasma Biomarker

n

Correlation With AUC0-tau

r

P Value

IL-6

19

-0.100

.683

IL-8

19

-0.202

.407

IL-10

19

0.061

.802

VEGF

19

0.496

.030

PDGF-BB

19

-0.161

.509

HGF

25

0.263

.203

SCF

25

-0.210

.313

SDF1α

25

0.806

< .0001

sVEGFR1

25

-0.378

.062

sVEGFR2

25

-0.916

< .0001

  1. The concentrations of plasma proteins were measured at baseline and at day 8 of lenvatinib treatment, and the percentage change from baseline was analyzed in correlation with AUC0-tau. Spearman’s correlation coefficient (r) and P value (p) for each analysis is listed.
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BMC Cancer

ISSN: 1471-2407

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