Figure 1From: Stability of the CpG island methylator phenotype during glioma progression and identification of methylated loci in secondary glioblastomas Clustering analysis. 1a. Hierarchical euclidean based clustering of the 2000 most variable loci. Samples split into 2 major cluster groups designated as being either CIMP+ve or CIMP-ve with each major cluster splitting into 2 sub-groups. Normal samples clustered together and are labeled N1-N4, tumor samples are labeled with their pair number (P#) followed by either E or L to denote early or late lesion respectively. 1b. Box and whisker plots of cluster group ANOVAs. 1c. CIMP status as determined by clustering is shown with a black or white circle representing CIMP+ve and CIMP-ve respectively. IDH1 mutation status is shown as either mutant (mut) or wild-type (wt) for the p.R132H change.Back to article page