From: A cross-sectional study of global DNA methylation and risk of colorectal adenoma
LINE-1 methylation quartile | Normal | Adenoma | Â | Â | Adjusted* | Â | |||
---|---|---|---|---|---|---|---|---|---|
N | (%) | N | (%) | OR | (95% CI) | OR | 95% (CI) | p-value** | |
Both sexes*** | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 Low | 52 | (60%) | 35 | (40%) | 2.23 | (1.10-4.51) | 2.26 | (1.11-4.58) | 0.02 |
2 | 53 | (63%) | 31 | (37%) | 1.94 | (0.95-3.95) | 2.01 | (0.98-4.11) | 0.06 |
3 | 51 | (66%) | 26 | (34%) | 1.69 | (0.81-3.51) | 1.68 | (0.80-3.50) | 0.17 |
4 High | 53 | (77%) | 16 | (23%) | 1.00 | referent | 1.00 | referent | Â |
Standardized continuous | Â | Â | 0.87 | (0.69-1.10) | 0.85 | (0.68-1.08) | 0.19 | ||
Males | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 (79.87 - 87.42) | 16 | (42%) | 22 | (58%) | 2.60 | (0.92-7.30) | 2.94 | (1.02-8.47) | 0.05 |
2 (87.43 - 89.55) | 17 | (44%) | 22 | (46%) | 2.44 | (0.88-6.82) | 2.85 | (0.99-8.18) | 0.05 |
3 (89.56 - 92.06) | 15 | (44%) | 19 | (56%) | 2.39 | (0.83-6.87) | 2.52 | (0.87-7.32) | 0.09 |
4 (92.07 - 95.94) | 17 | (65%) | 9 | (35%) | 1.00 | referent | 1.00 | referent | Â |
Standardized continuous | Â | Â | 0.84 | (0.60-1.81) | 0.80 | (0.56-1.14) | 0.21 | ||
Females | Â | Â | Â | Â | Â | Â | Â | Â | Â |
1 (75.13 - 85.59) | 36 | (73%) | 13 | (27%) | 1.86 | (0.66-5.19) | 1.80 | (0.64-5.05) | 0.26 |
2 (85.60 - 87.86) | 36 | (80%) | 9 | (20% | 1.29 | (0.43-3.83) | 1.27 | (0.43-3.79) | 0.67 |
3 (87.87 - 89.95) | 36 | (84%) | 7 | (16%) | 1.00 | (0.32-3.14) | 0.98 | (0.31-3.07) | 0.97 |
4 (89.96 - 97.95) | 36 | (84%) | 7 | (16%) | 1.00 | referent | 1.00 | referent | Â |
Standardized continuous | Â | Â | 0.87 | (0.60-1.25) | 0.87 | (0.60-1.25) | 0.44 |