Matrix metalloproteinase 1 and circulating tumor cells in early breast cancer

BMC Cancer

Table 2 MMP1 expression in tumor cells and tumor stroma

Variable		MMP1 expression histoscore in tumor cells				MMP1 expression histoscore in tumor associated stroma
Variable	N	Mean	SEM	Median	P-value	Mean	SEM	Median	P-value
All	149	32.8	3.4	15	NA	49.1	5.1	20	NA
T-stage
1	105	30.6	4.0	14	0.28	49.7	6.1	20	0.76
> 1	44	44.0	38.2	17		43.0	47.6	20
N-stage
0	91	32.1	4.4	14	1.00	44.7	6.5	20	0.29
> 1	58	34.0	5.5	18		55.9	8.1	20
Grade
1 and 2	95	27.0	4.2	10	0.007	37.9	6.2	6	0.0006
3	54	43.2	5.6	30		69.2	8.3	50
Histology
IDC	128	34.3	3.7	20	0.15	53.8	5.4	20	0.0022
Other	21	23.6	9.0	4		20.8	13.3	1
Hormone receptor status
Negative	19	42.0	9.5	20	0.26	70.7	14.5	50	0.18
Positive	130	31.5	3.6	13		46.1	5.4	20
HER2 status
Negative	127	30.4	3.7	10	0.18	45.0	5.5	20	0.29
Amplified	22	47.1	8.8	25		72.5	13.1	40
Ki 67 (cut-off 20%)
Low	92	28.6	4.3	10	0.04	34.7	6.2	10	0.0006
High	56	39.7	5.5	25		72.8	7.9	50
Lymphovascular invasion
Present	35	41.0	7.0	20	0.10	48.2	10.5	20	0.83
Absent	114	30.3	3.9	11		49.4	5.8	20
Baseline CTC
CTC Epithelial
Negative	133	32.9	3.6	16	0.35	48.6	5.4	20	0.50
Positive	16	32.1	10.4	3		53.0	15.5	11
CTC EMT
Negative	126	30.2	3.7	10	0.02	45.7	5.5	20	0.05
Positive	23	47.0	8.6	40		68.5	13.1	50
CTC Any
Negative	113	31.3	3.9	10	0.47	47.9	5.8	20	0.75
Positive	36	37.5	6.9	20		53.0	10.5	20

ISSN: 1471-2407