Figure 1

B-mode, elastonosonography and contrast enhanced ultrasonography with VEGFR2 targeted microbubbles images. B-mode ultrasonography (panel A) was used to calculate tumor dimensions whereas elastosonography (panel B) allowed to evaluate the elasticity of the tumor with respect to a pad with costant elasticity. Elasticity ratio is reported (ELX2/1) as well as histogram of elasticity distribution. In panel C, contrast enhanced ultrasonography with VEGFR2 targeted microbubbles images immediately before the high mechanical index flash (5 minutes and 59 seconds) is shown (upper part of the panel). Time intensity curve (lower part of panel C) was created using a dedicated software to calculate differential targeted enhancement (dTE).