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Table 2 Gender-specific incidence density rates and SIRs for cancer sites

From: Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan

 

General population(a)

Population with type2 diabetes

Main analysis using outpatient and inpatient databases

After excluding cancer cases diagnosed within 1 year of entry(b)

Using Registry for Catastrophic Illness Database(c)

Type of cancer

O

Incidence density#

O

Incidence density#

SIR

95% CI

SIR

95% CI

SIR

95% CI

Men

          

  Lung

53072

1.14

7493

3.64

0.99

(0.97-1.02)

0.96

(0.94-0.99)**

0.74

(0.72-0.77)***

  Liver

64321

1.39

9375

4.57

1.61

(1.57-1.64)***

1.59

(1.55-1.62)***

1.70

(1.65-1.76)***

  Colorectal

46715

1.01

6048

2.92

1.19

(1.15-1.22)***

1.16

(1.13-1.20)***

1.12

(1.07-1.17)***

  Stomach

18918

0.41

2528

1.21

0.96

(0.92-1.00)*

0.96

(0.92-1.00)

0.89

(0.85-0.95)***

  Oral

30942

0.67

2411

1.15

1.16

(1.12-1.21)***

1.15

(1.10-1.21)***

1.09

(1.03-1.15)**

  Prostate

27767

0.60

4259

2.05

0.96

(0.93-0.99)*

0.94

(0.91-0.97)***

0.89

(0.85-0.94)***

  Esophagus

11667

0.25

1073

0.51

0.88

(0.82-0.94)***

0.88

(0.82-0.94)***

0.69

(0.63-0.75)***

  Pancreas

7023

0.15

1337

0.64

1.62

(1.53-1.72)***

1.56

(1.46-1.67)***

1.60

(1.45-1.77)***

  Cervix

-

-

-

-

-

-

-

-

-

-

  Nasopharyngeal

20022

0.43

1251

0.60

1.09

(1.03-1.16)***

1.04

(0.98-1.11)

0.85

(0.76-0.95)**

  Small intestine

2129

0.05

287

0.14

1.15

(1.02-1.31)*

1.11

(0.97-1.28)

0.82

(0.64-1.05)

  Gallbladder

4522

0.10

693

0.33

1.18

(1.08-1.28)***

1.15

(1.05-1.25)**

1.10

(0.97-1.25)

  Retroperitoneum and peritoneum

1274

0.03

160

0.08

1.19

(1.00-1.40)*

1.14

(0.95-1.37)

1.06

(0.74-1.51)

  Larynx

6821

0.15

596

0.28

0.84

(0.77-0.91)***

0.83

(0.79-0.91)***

0.75

(0.65-0.85)***

  Respiratory and intrathoratic organs

7399

0.16

745

0.36

0.93

(0.86-1.00)

0.90

(0.83-0.98)*

0.81

(0.65-1.00)*

  Bone

3778

0.08

350

0.17

0.93

(0.83-1.04)

0.90

(0.79-1.01)

0.90

(0.64-1.26)

  Connective and other soft tissue

4536

0.10

428

0.20

1.07

(0.96-1.18)

1.06

(0.95-1.18)

0.81

(0.64-1.03)

  Skin

1605

0.03

199

0.09

1.10

(0.95-1.28)

1.08

(0.92-1.27)

1.10

(0.85-1.43)

  Testis

2017

0.04

127

0.06

1.16

(0.96-1.40)

1.18

(0.97-1.44)

0.71

(0.34-1.47)

  Penis

1132

0.02

148

0.07

1.88

(1.57-2.25)***

1.41

(1.16-1.71)***

1.32

(0.96-1.82)

  Bladder

12758

0.27

1802

0.86

1.07

(1.02-1.13)**

1.04

(0.99-1.10)

0.99

(0.92-1.06)

  Kidney

9913

0.21

1504

0.72

1.32

(1.25-1.40)***

1.30

(1.22-1.38)***

1.28

(1.17-1.40)***

  Brain

7596

0.16

732

0.35

1.03

(0.96-1.12)

0.99

(0.91-1.08)

0.77

(0.65-0.92)**

  Hodgkin’s disease

760

0.02

106

0.05

1.69

(1.37-2.10)***

1.42

(1.11-1.81)**

1.05

(0.63-1.73)

  Leukemia

4917

0.11

928

0.44

1.86

(1.73-2.00)***

1.66

(1.54-1.80)***

0.96

(0.84-1.09)

  Carcinoma in situ

11323

0.24

1251

0.60

1.18

(1.11-1.25)***

1.15

(1.07-1.23)***

0.81

(0.18-3.58)

Women

          

  Lung

24872

0.66

4498

2.11

0.98

(0.95-1.02)

0.97

(0.94-1.00)

0.74

(0.70-0.78)***

  Liver

28577

0.75

6061

2.85

1.55

(1.51-1.60)***

1.54

(1.49-1.58)***

1.67

(1.60-1.75)***

  Colorectal

33469

0.88

5502

2.59

1.16

(1.13-1.20)***

1.15

(1.11-1.18)***

1.07

(1.01-1.12)***

  Breast

42441

1.12

2934

1.37

1.14

(1.09-1.18)***

1.13

(1.09-1.18)***

1.09

(1.04-1.14)***

  Stomach

9632

0.25

1830

0.85

1.11

(1.05-1.17)***

1.12

(1.06-1.18)***

1.05

(0.98-1.13)

  Oral

4970

0.13

733

0.34

1.30

(1.20-1.42)***

1.27

(1.16-1.39)***

1.08

(0.94-1.25)

  Esophagus

7500

0.20

648

0.30

1.08

(0.99-1.18)

1.06

(0.97-1.16)

0.70

(0.54-0.90)**

  Pancreas

4700

0.12

1071

0.50

1.44

(1.34-1.55)***

1.42

(1.32-1.53)***

1.31

(1.17-1.46)***

  Cervix

27472

0.73

2579

1.21

0.94

(0.90-0.99)**

0.93

(0.89-0.98)**

0.84

(0.79-0.90)***

  Nasopharyngeal

8789

0.23

690

0.32

1.14

(1.05-1.24)**

1.09

(0.99-1.19)

0.98

(0.82-1.18)

  Small intestine

1248

0.03

222

0.10

1.11

(0.96-1.29)

1.04

(0.88-1.22)

1.04

(0.81-1.34)

  Gallbladder

3278

0.09

697

0.32

1.10

(1.01-1.20)*

1.08

(0.99-1.19)

1.08

(0.96-1.22)

  Retroperitoneum and peritoneum

1358

0.04

201

0.09

1.16

(0.99-1.35)

1.13

(0.95-1.33)

1.16

(0.89-1.52)

  Larynx

1272

0.03

137

0.06

1.30

(1.07-1.57)**

1.35

(1.10-1.66)**

1.41

(0.87-2.27)

  Respiratory and intrathoratic organs

3889

0.10

495

0.23

0.94

(0.85-1.04)

0.92

(0.83-1.02)

0.66

(0.50-0.88)**

  Bone

2555

0.07

333

0.15

1.03

(0.91-1.16)

1.00

(0.88-1.14)

0.78

(0.52-1.18)

  Connective and other soft tissue

3284

0.09

309

0.14

0.86

(0.76-0.97)*

0.84

(0.73-0.95)**

0.76

(0.58-0.99)*

  Skin

1265

0.03

189

0.09

1.10

(0.94-1.29)

0.99

(0.83-1.18)

0.93

(0.71-1.22)

  Placenta

450

0.01

385

0.18

19.90

(16.40-24.16)***

8.74

(6.65-11.48)***

1.59

(0.44-5.74)

  Endometrium

8094

0.21

835

0.39

1.36

(1.26-1.47)***

1.28

(1.18-1.39)***

1.32

(1.17-1.49)***

  Ovary

13406

0.35

873

0.41

1.02

(0.95-1.10)

1.02

(0.94-1.10)

0.85

(0.75-0.96)**

  Bladder

6043

0.16

1151

0.54

1.19

(1.11-1.27)***

1.17

(1.09-1.25)***

1.13

(1.03-1.25)*

  Kidney

6943

0.18

1471

0.68

1.38

(1.30-1.46)***

1.36

(1.28-1.45)***

1.32

(1.21-1.45)***

  Brain

6370

0.17

791

0.37

1.15

(1.06-1.25)***

1.10

(1.01-1.20)*

0.80

(0.66-0.97)*

  Hodgkin’s disease

543

0.01

91

0.04

1.84

(1.44-2.35)***

1.82

(1.38-2.39)***

1.35

(0.64-2.87)

  Leukemia

3353

0.09

830

0.39

2.11

(1.94-2.29)***

1.84

(1.68-2.03)***

0.96

(0.83-1.12)

  Carcinoma in situ

49189

1.30

3142

1.47

0.93

(0.90-0.97)***

0.92

(0.88-0.96)***

1.05

(0.36-3.06)

  1. (a) The SIR for general population is 1.00.
  2. (b) Observed number of cancer cases for population with type 2 diabetes after exclusion of cancers diagnosed within 1 year of cohort entry.
  3. (c) Observed number of cancer cases for population with type 2 diabetes using Registry of Catastrophic Illness Database
  4. SIRs were adjusted for covariates (insurance premium, urbanization degree of area registered for National Health Insurance program, and age).
  5. Bold type indicates that the 95% CI does not include 1.00. Abbreviations: CI confidence interval, O observed number of cancer cases, SIR standardized incidence ratio. #: per 1000 person-years; *: p < 0.05; **: p < 0.01; ***: p < 0.001.
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BMC Cancer

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