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Table 4 Crude and adjusted hazard ratio (95% CI) of risk factors for CRC recurrence by univariate and multivariate competing-risks regression analysis

From: Health-related quality of life and risk of colorectal cancer recurrence and All-cause death among advanced stages of colorectal cancer 1-year after diagnosis

 

Crude SHRa

Adjusted SHR (FACT-C domain)a

Adjusted SHR (SF-12 domain)a

Adjusted SHR (SF-6D)a

 

Estimate

95% CI

P-value

Estimate

95% CI

P-value

Estimate

95% CI

P-value

Estimate

95% CI

P-value

Primary Tumour Site (Colon)

            

  Rectum

1.173

(0.513,2.682)

0.705

1.084

(0.152,7.754)

0.936

1.419

(0.149,13.555)

0.761

1.121

(0.256,4.912)

0.880

Active CRC Treatment (No)

            

  Yes

3.891

(1.663,9.102)

0.002b

4.724

(0.812,27.477)

0.084

2.871

(0.824,10.006)

0.098

2.424

(0.771,7.617)

0.130

Stoma (Present)

            

  Absent

0.474

(0.179,1.254)

0.133

0.375

(0.078,1.814)

0.223

0.864

(0.145,5.159)

0.873

0.845

(0.205,3.484)

0.815

Time Since Diagnosis, months

0.984

(0.963,1.006)

0.152

0.998

(0.974,1.023)

0.892

1.002

(0.985,1.019)

0.817

0.992

(0.970,1.014)

0.481

AJCC (Stage III)

            

  Stage IV

4.002

(1.777,9.016)

<0.001b

2.469

(0.413,14.743)

0.322

6.225

(1.144,33.866)

0.034b

3.965

(1.222,12.862)

0.022b

FACT-C

            

  PWB

0.949

(0.890,1.011)

0.103

0.925

(0.765,1.119)

0.424

      

  SWB

1.042

(0.899,1.208)

0.583

1.067

(0.842,1.352)

0.593

      

  EWB

0.925

(0.831,1.029)

0.152

0.880

(0.702,1.102)

0.265

      

  FWB

1.001

(0.930,1.077)

0.988

1.022

(0.847,1.233)

0.821

      

  CCS

1.059

(0.921,1.217)

0.420

1.281

(0.980,1.674)

0.069

      

SF-12

            

  PF

0.989

(0.978,1.000)

0.053

   

1.001

(0.970,1.033)

0.950

   

  RP

0.981

(0.968,0.994)

0.005b

   

0.972

(0.945,1.001)

0.058

   

  BP

0.993

(0.978,1.009)

0.398

   

0.992

(0.958,1.028)

0.663

   

  GH

0.998

(0.983,1.013)

0.770

   

1.002

(0.972,1.034)

0.877

   

  VT

0.998

(0.972,1.024)

0.852

   

1.009

(0.966,1.054)

0.690

   

  SF

0.989

(0.978,1.001)

0.070

   

1.008

(0.981,1.035)

0.569

   

  RE

1.008

(0.980,1.036)

0.579

   

1.036

(0.967,1.110)

0.319

   

  MH

1.015

(0.973,1.059)

0.478

   

1.028

(0.977,1.082)

0.286

   

SF-6D

0.057

(0.004,0.888)

0.041b

      

0.503

(0.022,11.259)

0.665

AIC

   

187.4

202.5

199.4

BIC

   

243.5

267.5

244.7

  1. Note: SHR = Sub-Hazard ratio.
  2. FACT-C subscales: PWB = physical well-being; SWB = social well-being; EWB = emotional well-being; FWB = functional well-being; CCS = colorectal cancer subscale;
  3. SF-12 subscales: PF = physical functioning; RP = role physical; BP = bodily pain; GH = general health; VT = vitality; SF = social functioning; RE = role emotional; MH = mental health.
  4. aSHR > 1 indicates greater risk for CRC recurrence, with adjustment of socio-demographic characteristics.
  5. bp-value < 0.05.
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BMC Cancer

ISSN: 1471-2407

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