Table 2 Univariate and multivariate analyses of Sirt3 associated with recurrence and survival
| Â | TTR | OS | ||||
|---|---|---|---|---|---|---|
| Â | Univariate | Multivariate | Univarate | Multivariate | ||
| Â | P value | H.R. (95% CI) | P value | P value | H.R. (95% CI) | P value |
BCLC stage A | Â | Â | Â | Â | Â | Â |
γ-GT, U/L (≤54 vs >54) | 0.003 | 1.646 (1.091–2.484) | 0.016 | 0.003 | 1.718 (1.051–2.810) | 0.028 |
AFP, ng/ml (≤20 vs >20) | 0.013 | 1.574 (1.033–2.398) | 0.032 | 0.060 | NA | NA |
Tumor size, cm (≤5 vs >5) | <0.001 | 2.292 (1.515–3.470) | <0.001 | <0.001 | 3.150 (1.952–5.084) | <0.001 |
Tumor number (single vs multiple) | 0.948 | NA | NA | 0.726 | NA | NA |
Tumor capsule (yes vs no) | 0.296 | NA | NA | 0.690 | NA | NA |
Differentiation (well vs poor) | 0.429 | NA | NA | 0.550 | NA | NA |
Mean density score (low vs high) | Â | Â | Â | Â | Â | Â |
iSirt3(2) | 0.008 | 0.591 (0.396–0.884) | 0.011 | <0.001 | 0.404 (0.251–0.650) | <0.001 |
pSirt3(4) | 0.020 | 0.538 (0.316–0.914) | 0.022 | 0.278 | NA | NA |
TMA assays | Â | Â | Â | Â | Â | Â |
Age, year (≤52 vs >52) | 0.173 | NA | NA | 0.787 | NA | NA |
Gender (female vs male) | 0.616 | NA | NA | 0.654 | NA | NA |
HBV infection (no vs yes) | 0.903 | NA | NA | 0.168 | NA | NA |
Liver cirrhosis (no vs yes) | 0.803 | NA | NA | 0.225 | NA | NA |
ALT, U/L (≤75 vs >75) | 0.177 | NA | NA | 0.225 | NA | NA |
γ-GT, U/L (≤54 vs >54) | <0.001 | 1.563 (1.121–2.177) | 0.008 | <0.001 | 1.471 (1.003–2.159) | 0.046 |
AFP, ng/ml (≤20 vs >20) | 0.004 | 1.474 (1.048–2.072) | 0.023 | 0.014 | 1.379 (0.936–2.031) | 0.098 |
Tumor size, cm (≤5 vs >5) | <0.001 | 1.830 (1.314–2.549) | <0.001 | 0.000 | 2.919 (2.019–4.220) | <0.001 |
Tumor number (single vs multiple) | 0.057 | NA | NA | 0.069 | NA | NA |
Tumor capsule (yes vs no) | 0.096 | NA | NA | 0.167 | NA | NA |
Differentiation (well vs poor) | 0.162 | NA | NA | 0.124 | NA | NA |
Tumor thrombi (no vs yes) | 0.001 | 1.506 (1.072–2.116) | 0.021 | <0.001 | 1.658 (1.146–2.399) | 0.009 |
TNM stage (I vs II/III) | <0.001 | NA | NA | <0.001 | NA | NA |
BCLC stage (A vs B/C) | 0.001 | NA | NA | <0.001 | NA | NA |
Mean density score (low vs high) | Â | Â | Â | Â | Â | Â |
iSirt3(2) | 0.011 | 0.705 (0.514–0.967) | 0.031 | 0.001 | 0.558 (0.392–0.795) | 0.001 |
pSirt3(4) | 0.017 | 0.674 (0.450–1.009) | 0.047 | 0.023 | 0.611 (0.381–0.979) | 0.031 |