Table 1 Baseline patient demographics and clinical characteristics
Demographics or Clinical characteristics | Arm I: Axitinib (Continuous) + Pem/Cis | Arm II: Axitinib (Modified) + Pem/Cis | Arm III: Pem/Cis Alone |
|---|---|---|---|
n= 55 | n= 58 | n= 57 | |
Age, yr, median (range) | 62 (30–77) | 62 (35–83) | 59 (42–76) |
Gender, n (%) | |||
Male | 34 (62) | 37 (64) | 37 (65) |
Female | 21 (38) | 21 (36) | 20 (35) |
Race, n (%) | |||
White | 39 (71) | 49 (84) | 45 (79) |
Black | 0 | 1 (2) | 0 |
Asian | 15 (27) | 8 (14) | 12 (21) |
Other | 1 (2) | 0 | 0 |
Smoking status, n (%) | |||
Never smoked | 15 (27) | 9 (16) | 12 (21) |
Smokera | 40 (73) | 49 (84) | 45 (79) |
ECOG PS, n (%) | |||
0 | 25 (45) | 25 (43) | 27 (47) |
1 | 30 (55) | 33 (57) | 28 (49) |
Not reported | 0 | 0 | 2 (4) |
Histological classification, n (%) | |||
Adenocarcinoma | 53 (96) | 52 (90) | 47 (82) |
Large cell | 1 (2) | 3 (5) | 8 (14) |
Bronchioloalveolar | 0 | 2 (3) | 2 (4) |
Other | 1 (2) | 1 (2) | 0 |
Disease stage at baseline, n (%) | |||
Stage IIIB | 3 (5) | 6 (10) | 4 (7) |
Stage IV | 46 (84) | 50 (86) | 52 (91) |
Recurrent | 6 (11) | 2 (3) | 1 (2) |
Prior therapy, n (%) | |||
Resectionb | 14 (25) | 12 (21) | 16 (28) |
Radiation | 11 (20) | 7 (12) | 8 (14) |