Figure 2
From: Levels of active tyrosine kinase receptor determine the tumor response to Zalypsis
Correlation of markers with trabectedin and Zalypsis cytotoxicity. A) Statistically relevant (p < 0.005) correlations of molecular markers with trabectedin or Zalypsis treatment. The number indicates the correlation coefficient between the marker and the drug. B and C) Statistical graphs showing the correlation between individual markers and responses in the log rank test or Student t-test. The p value shows the statistical relevance of these correlations. B) Correlation of p53 mutations and the trabectedin IC50 (nM). M: mutant p53; WT: wild-type p53. C) Correlation of PDGFR/PDGFR + c-Kit and the Zalypsis IC50. D) Expression of PDGFRα and c-Kit proteins across the cell line panel and correlation with sensitivity (IC50 values) to Zalypsis.