Table 1 Uni- and multivariate analyses for Overall Survival (OS) and Disease Free Survival (DFS) on patient/tumor characteristics and uPAR expression in tumor-associated stromal cells and neoplastic cells (and both combined) from 262 colorectal tumor patients are displayed

Clinical data (total)

262

Age in years

<65

109

1.000

0.000

1.000

0.000

1.000

0.000

1.000

0.000

≥65

153

3.381

2.360-4.842

3.648

2.537-5.245

3.058

2.172-4.307

3.309

2.338-4.682

TNM

Stage I

47

1.000

0.000

1.000

0.000

1.000

0.000

1.000

0.000

Stage II

97

1.522

0.910-2.547

1.699

1.013-2.850

1.513

0.927-2.469

1.686

1.030-2.760

Stage III/IV

118

3.590

2.208-5.838

4.034

2.473-6.580

3.199

2.006-5.102

3.560

2.223-5.700

Differentiation^I

Grade 1

49

1.000

0.451

1.000

0.663

Grade 2+

158

1.174

0.773-1.783

1.093

0.733-1.630

MSI^II

MSS

184

1.000

0.457

1.000

0.429

MSI

26

0.816

0.477-1.396

0.815

0.491-1.353

Size^III in mm

<50

179

1.000

0.589

1.000

0.396

≥50

82

1.093

0.791-1.511

1.146

0.837-1.568

Mucinous^IV

No

220

1.000

0.447

1.000

0.248

yes

36

0.850

0.558-1.293

0.790

0.529-1.179

uPAR in tumor cells

Low

152

1.000

0.036

1.000

0.177

1.000

0.037

1.000

0.318

High

110

1.387

1.021-1.883

1.241

0.907-1.697

1.372

1.019-1.848

1.168

0.861-1.585

uPAR in stromal cells

Neg

38

1.000

0.033

1.000

0.067

1.000

0.014

1.000

0.031

Pos

224

1.688

1.044-2.729

1.580

0.968-2.578

1.819

1.127-2.936

1.713

1.049-2.796

Combined uPAR expression^V

Neg

38

1.000

0.032

1.000

0.037

1.000

0.019

1.000

0.032

Pos/Low

119

1.508

0.909-2.501

1.503

0.905-2.495

1.646

0.995-2.724

1.661

1.002-2.754

Pos/High

105

1.925

1.159-3.198

1.906

1.146-3.170

2.036

1.230-3.370

1.959

1.182-3.247