Table 5 Univariate associations of HSCORE for NILCO and targets with EGFR and AR
From: NILCO biomarkers in breast cancer from Chinese patients
EGFR | AR | |||||
|---|---|---|---|---|---|---|
Antigen | Negative (N=52) | Positive (N=15) | P-value* | Negative (N=40) | Positive (N=27) | P-value* |
Notch1 | 2.44 (1.78- 3.06) | 2.89 (2.28-3.50) | 0.018 | 2.49 (1.84-3.09) | 2.62 (1.99-3.25) | 0.403 |
Negative | 1 (1.92) | 0 (0) | 1.000 | 1 (2.5) | 0 (0) | 1.000 |
Positive | 51 (98.08) | 15 (100) | 39 (97.5) | 27 (100) | ||
Notch4 | 1.55 (1–3.48) | 1.81 (1–2.5) | 0.782 | 1.62 (1–3.48) | 1.7 (1–2.5) | 0.966 |
Negative | 12 (25) | 3 (20) | 1.000 | 10 (27.03) | 5 (19.23) | 0.474 |
Positive | 36 (75) | 12 (80) | 27 (72.97) | 21 (80.77) | ||
JAG1 | 1.35 (1–3) | 1.17 (1–2.09) | 0.215 | 1.28 (1–2.43) | 1.23 (1–3) | 0.510 |
Negative | 13 (25) | 6 (40) | 0.332 | 13 (32.5) | 6 (22.22) | 0.360 |
Positive | 39 (75) | 9 (60) | 27 (67.5) | 21 (77.78) | ||
DLL4 | 3.15 (1.91 - 3.87) | 3.27 (1.19 - 3.66) | 0.443 | 3.19 (1.19 - 3.65) | 3.15 (2–3.87) | 0.828 |
Negative | NA | NA | NA | NA | NA | NA |
Positive | 52 (100) | 15 (100) | 40 (100) | 27 (100) | ||
Leptin | 3.07 (1–4) | 2.69 (1–4) | 0.825 | 2.88 (1–4) | 3.02 (1–4) | 0.938 |
Negative | 16 (30.77) | 5 (33.33) | 1.000 | 12 (30) | 9 (33.33) | 0.773 |
Positive | 36 (69.23) | 10 (66.67) | 28 (70) | 18 (66.67) | ||
OB-R | 1.09 (1–2.3) | 1.05 (1–1.26) | 0.338 | 1.1 (1–2.27) | 1.06 (1–2.3) | 0.359 |
Negative | 17 (32.69) | 5 (33.33) | 1.000 | 12 (30) | 10 (37.04) | 0.547 |
Positive | 35 (67.31) | 10 (66.67) | 28 (70) | 17 (62.96) | ||
IL-1R tI | 3.67 (1–4) | 3.52 (1.56 - 4) | 0.255 | 3.53 (1–4) | 3.86 (2.46 - 4) | 0.026 |
Negative | 1 (1.92) | 0 (0) | 1.000 | 1 (2.5) | 0 (0) | 1.000 |
Positive | 51 (98.08) | 15 (100) | 39 (97.5) | 27 (100) | ||
VEGF | 3.64 (1.04 - 4) | 3.81 (2.45 - 4) | 0.625 | 3.67 (1.04 - 4) | 3.74 (2.83 - 4) | 0.635 |
Negative | NA | NA | NA | NA | NA | NA |
Positive | 52 (100) | 15 (100) | 40 (100) | 27 (100) | ||
VEGFR2 | 1 (1–2) | 1 (1–2) | 0.957 | 1 (1–2) | 1 (1–2) | 0.757 |
Negative | 34 (65.38) | 10 (66.67) | 0.927 | 27 (67.5) | 17 (62.96) | 0.701 |
Positive | 18 (34.62) | 5 (33.33) | 13 (32.5) | 10 (37.04) | ||