Figure 2

Processes and outcomes involving leptin, OB-R, Notch1, Notch4, IL-1R tI, JAG1, DLL4, VEGF, VEGFR2 (KDR), EGFR, AR and Ki67 (MKi67 gene) in the development of breast neoplasms. Breast cancers showed a quantitative increase in the expression of leptin, OB-R, Notch1, Notch4, DLL4, JAG1, IL-1R tI, VEGF, VEGFR2, EGFR, AR and Ki67. Increased expression of leptin, Notch1, Notch4, JAG1, and VEGF upregulated the development of breast neoplasms. Elevated levels of leptin, OB-R, Notch1, DLL4, VEGF, AR, EGFR and Ki67 proteins are reported to be biomarkers for breast cancers (data obtained from 1064 references; see Additional file 1; Pathway Studio9, Ariadine Genomics).