Table 2 Prognostic impacts of clinicopathological variables computed by Cox’s univariate and multivariate analyses in patients with primary breast cancer
Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|
Hazard ratio | (95% CI) | P-value | Hazard ratio | (95%CI) | P-value | ||
Disease free survival | |||||||
Nucleostemin | Negative | 1 | 0.023 | 1 | 0.036 | ||
Positive | 2.06 | (1.11-3.84) | 2.13 | (1.05-4.33) | |||
Hormone-receptor | Positive | 1 | 0.045 | 1 | 0.46 | ||
Negative | 1.73 | (1.01-2.95) | 0.78 | (0.39-1.52) | |||
HER2 | Negative | 1 | 0.0005 | 1 | 0.17 | ||
Positive | 2.91 | (1.59-5.34) | 1.65 | (0.80-3.41) | |||
Nuclear grade | 1, 2 | 1 | <0.0001 | 1 | 0.0008 | ||
3 | 3.30 | (1.94-5.64) | 2.97 | (1.57-5.61) | |||
Tumor size | ≦5.0 cm | 1 | <0.0001 | 1 | 0.0007 | ||
>5.0 cm | 6.89 | (3.97-11.9) | 2.99 | (1.59-5.66) | |||
Nodal status | Negative | 1 | <0.0001 | 1 | 0.0038 | ||
Positive | 4.51 | (2.45-8.31) | 2.73 | (1.38-5.38) | |||
Distant metastasis | Negative | 1 | <0.0001 | 1 | <0.0001 | ||
Positive | 71.6 | (26.1-196.5) | 62.3 | (15.5-251.1) | |||