Table 3 Studies on EGFR, KRAS, PIK3CA and PTEN mutations in Esophageal cancer
Gene | Reference | No. | Pathology | Exon examined | Mutated codon with amino acid | Mutation detated N (%) |
|---|---|---|---|---|---|---|
EGFR | Kwak et al. [4] | 17 | EAC | 18-21 | L858R, E746-A750del | 2 (11.76) |
Guo et al. [6] | 10 | EAC | 18-21 | A734P | 1 (10.00) | |
57 | ESCC | E872, G873, P753 | 3 (5.26) | |||
17 | ESCC (cell line) | S768I (Exon20) | 1 (5.88) | |||
Janmaat et al. [7] | 26 | NR | 18-21 | - | 0 | |
Hanawa et al. [15] | 40 | ESCC | 19,21 | - | 0 | |
Puhringer et al. [9] | 105 | BAC | 19,21 | K754 | 1 (0.95) | |
Sudo et al. [5] | 1 | EAC (cell line) | 18-21 | 2607G > A (Exon20) | 1 (100) | |
18 | ESCC (cell line) | NR | 2 (11.11) | |||
50 | NR | G719D | 1 (2.00) | |||
Mir et al. [14] | 54 | ESCC | 18-21 | codon 746–750, codon 753, codon 719 (Exon 19) | 3 (5.56) | |
Sunpaweravong et al. [13] | 48 | ESCC | 19,21 | - | 0 | |
Kaneko et al. [12] | 57 | ESCC | 18-21 | codon 787 (Exon 20) | 19 (33.33) | |
Marx et al. [19] | 20 | BAC | 18-21 | - | 0 | |
Liu et al. [11] | 50 | ESCC | 18-21 | G719X, L858R, Exon9 in-frame deletion | 7 (14.00) | |
Tasioudi et al. [20] | 44 | ESCC | 18-21 | - | 0 | |
Wang et al. [10] | 65 | adenocarcinoma of esophagogastric junction | 18-21 | codon 787 2361G- > A (Exon20) | 19 (29.23) | |
Maeng et al. [23] | 70 | ESCC | NR | P733L | 1 (1.43) | |
Kato et al. [29] | 107 | ESCC | NR | del745-750 | 1 (0.93) | |
KRAS | Lord et al. [21] | 23 | EAC | 2 | Codon12 | 7 (30.43) |
Janmaat et al. [8] | 23 | NR | 2 | Codon12,13 | 2 (8.70) | |
Lyronis et al. [18] | 30 | ESCC | 2 | Codon12 | 5 (16.67) | |
Marx et al. [19] | 20 | BAC | 2-3 | NR | 1 (5.00) | |
Liu et al. [11] | 50 | ESCC | 2 | Codon12 | 6 (12.00) | |
Tasioudi et al. [20] | 44 | ESCC | 2 | Codon12 | 1 (2.27) | |
PIK3CA | Phillips et al. [24] | 35 | ESCC | 1-20 | G1624A, G1633A, G1635A (Exon9) C1027T (Exon4) | 4 (11.43) |
50 | EAC | G1624A (Exon9) | 3 (6.00) | |||
17 | BAC | - | 0 | |||
Janmaat et al. [7] | 24 | NR | 9,20 | - | 0 | |
Mori et al. [25] | 88 | ESCC | 9,20 | E545K,E545Q(Exon9) | 2 (2.27) | |
2 | ESCC (cell line) | E545K, E545Q(Exon9) | 2 (100) | |||
Akagi et al. [22] | 52 | ESCC | 1,9,20 | Exon9 | 4 (7.69) | |
Maeng et al. [23] | 70 | ESCC | 9,20 | E545K, E542K (Exon9), H1047R, H1047L (Exon20) | 9 (12.86) | |
PTEN | Hu et al. [28] | 33 | ESCC | 1-9 | 802-29 T - > C (Exon7) | 1 (3.03) |
492 + 8 T-deletion (Exon5) | 33 (100) | |||||
Hou et al. [26] | 3 | ESCC (cell line) | 1-9 | Exon2,5,6,8 in EC907 cells | 3 (100) | |
Exon5,8,9 in Eca cells | ||||||
Exon6,8,9 in EC1 cells |