Figure 3
Effect of ZA on tumor progression and metastasis dissemination. A. Comparison of tumor volume evolution between ZA (50 μg/kg, 3 times a week during 4 weeks) treated and non treated (PBS) nude mice in the A-673 Ewing’s sarcoma model; B: Histological comparison of lung metastases in mice 30 days after A-673 ES tumor cell injection in the medullar cavity of the tibia. ES cells were revealed by positive CD99 immunostaining. (left: Control mice, magnitude × 10; right: ZA treated mice, magnitude × 10). Both small (spontaneous, stars) and big (experimental, arrow) metastases can be seen in control mice whereas only a big one (arrow) is seen in ZA treated mice. These histology analyses are representative data of at least 6 mice/group.